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26 June 2020 | Story Nitha Ramanth | Photo Valentino Ndaba
Takudzwa Nyamunda.

Takudzwa Nyamunda is the proud new representative of the University of the Free State (UFS) for the 2020 Commonwealth Future Student Leadership programme. Nominated at a recent workshop themed ‘Reimagining Peace’, organised by the Association of Commonwealth Universities in collaboration with the British Council and the Durban University of Technology, Takudzwa demonstrated exceptional leadership, coupled with his experience of issues related to the UFS student committee, which provided the perfect foundation for his selection. 

“From a personal point of view, this was one of the most enriching experiences I have ever had, both in terms of the relationships established and the world knowledge gained. I am personally grateful for the opportunity to attend and would support any further initiative of this nature. I think the essence of this workshop was to encourage the young leaders present – all of whom were active citizens in their communities in one way or another – to continue fighting the good fight. The core message from the panellists was that it is all worth it in the end, and that even in the face of adversity and discouragement, we should keep fighting for the work we believe in,” says Takudzwa. 

Participants from 13 nations, including activists and thought leaders on non-violence affiliated with the International Centre of Nonviolence, the Gandhi Development Trust, and the Commonwealth Countering Violent Extremism Unit, contributed to the workshop. Over the course of three days, participants were divided into five groups and worked together on projects linked to three main themes – gender-based violence, global warming, and inequality.

The selection committee was convened by the Vice-Rector: Research and Internationalisation, Prof Corli Witthuhn, and facilitated by the Office for International Affairs. Currently in the final year of his Master of Industrial Psychology degree, Takudzwa’s wealth or experience includes being the founder and first president of the International Students Association (2016), and holder of the International Student portfolio as Student Representative Council (SRC) member (2017), coupled with being co-founder and first vice-chairperson of the South African Board for People Practices (SABPP): UFS Chapter and Vice-president of the SABPP National Youth Council (2019).

“I will continue to do what I have been doing for the past five years at the UFS, which is to make a difference in my sphere of influence”, says Takudzwa. 

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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