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06 March 2020 | Story Thabo Kessah | Photo Tsepo Moeketsi
Dr Ocaya
Dr Richard Ocaya’s research addresses the skills development and transfer millennium goal of many governments globally.

With the Fourth Industrial Revolution becoming a reality, Dr Richard Ocaya’s research is receptive to the fact that Africa and the world need to re-imagine their research. His research focuses on electronic instrumentation design for scientific measurements, computational physics on atomic nano-atomic structures, and semiconducting organic compounds materials built on silicon to realise Schottky devices.

Software developer 
“I develop most of the instrumentation that I apply in my research – both software and hardware,” said Dr Ocaya, a Physics Lecturer and Programme Director: Physics and Chemistry on the UFS Qwaqwa Campus.

“I am active in scientific computing through the computing cluster and software development, mathematical physics for material science modelling, and embedded instrumentation design using microprocessors. I also have deep interest in radio and data telemetry, in which I hold a South African patent issued in 2013. My present international collaborations are with like-minded researchers in similar fields in Saudi Arabia, Turkey, Japan, Egypt, South Korea, and the United States,” he added.

How does his research talk to the real world?
“The driving principle of all areas of my research has always been to deploy cutting-edge research to actual, real-world applications for the immediate betterment of Africans. The areas of my research align closely with the millennium goals of many governments globally, including the Republic of South Africa. These goals pertain to skills development and transfer that position us to better address the challenges of energy, water, and other priorities.”

Dr Ocaya is currently co-promoting a PhD student, having previously supervised one PhD, two MSc, and more than twenty honours students. He is a self-taught electronics and computer programmer, whose curiosity led him to question ‘the voices and music coming from a box; a radio’. “In my quest to satisfy my curiosity, I collected many discarded devices, took them apart, and tried so many circuits, only to have them fail because the theory was lacking. After thousands of failed projects and with me barely thirteen and in lower secondary school, my first ever project actually worked,” he said.

NRF-rating
He is the author of the book Introduction to Control Systems Analysis using Point Symmetries: An application of Lie Symmetries, which is available in all major bookstores such as Amazon, in both print and e-book format. He is a C3 NRF-rated researcher whose work makes a pioneering contribution to the new and growing field of phononics, an independent field of the now established photonics.

“This field will someday lead to improved energy-storage devices and faster processors due to more efficient heat removal from nanodevices,” he concludes.


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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