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09 March 2020 | Story Valentino Ndaba | Photo Sonia Small
Human Rights
Human Rights Month is a time to reflect on the past and celebrate the present.

On 21 March 2020, South Africa will celebrate Human Rights Day. The day has a specific meaning, as it commemorates the Sharpeville massacre which took place on 21 March 1960 in Sharpeville in the Vaal. After the community demonstrated against the pass laws, about 7,000 protesters went to the local police station where the South African Police opened fire on the crowd, killing 69 people and injuring 180.
 
The past, although dark and tragic, holds the power to propel a nation forward. Rector and Vice-Chancellor of the University of the Free State (UFS), Prof Francis Petersen, said: “In remembering this day, we have the opportunity to reflect on progress in the promotion and protection of human rights in South Africa.”
 
Prof Petersen expressed pride in the great strides made at the UFS in this regard and which are cause for celebration. “As a university community, let us join the rest of the country this month and celebrate the rights of all people to be protected from violation, irrespective of gender, race, sexual orientation, religion, etc. Let us observe this day and stand together to promote respect for human rights,” he said.

Policies with a purpose
UFS is guided by principles of non-discrimination and values which seek to uphold the rights of all humans as stipulated in the Constitution of the Republic of South Africa. Staff, students, and the general public enjoy the protection and dignity with policies such as Anti-Discrimination, Promotion of Equality and Social Justice Policy, the Sexual Harassment, Sexual Misconduct and Sexual Violence Policy, the Social Support Policy, as well as the Student Pregnancy Policy.

The objective of the Anti-Discrimination, Promotion of Equality, and Social Justice Policy is to clarify, deepen and promote an understanding of equality, social justice and unfair discrimination among the university community. In addition to other aims, it seeks to identify and promote an understanding of barriers to equality, as well as the various forms and practices of unfair discrimination that may occur. Preventing and eradicating such practices, identifying bullying practices within the various vertical and horizontal relationships at the university, is the policy’s ultimate mandate.

In a country plagued by gender-based violence and related crimes, the Sexual Harassment, Sexual Misconduct and Sexual Violence Policy becomes all the more significant. The policy’s purpose includes establishing a safe and enabling environment, free from sexual harassment, sexual misconduct and sexual violence, for all UFS community members. Support for victims and putting disciplinary procedures for perpetrators in place is a high priority within the policy. 

Human Rights are of utmost importance for a transforming institution such as ours. Hence, the Centre for Universal Access and Disability Support (CUADS) recently released the Social Support Policy Draft for public input. Its overarching goal is to establish an institutional climate and conditions that enable the UFS to retain its students and improve their chances of success by providing appropriate social support. 
 
As far as the Student Pregnancy Policy is concerned, creating conditions that are conducive for academic success and wellbeing during pregnancy is one of the ways in which the university upholds the human rights of mothers-to-be. The policy also ensures that pregnant students are not excluded from academic programmes, residences and other university activities.



News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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