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13 March 2020 | Story Leonie Bolleurs | Photo Leonie Bolleurs
Team from the UFS Microbiology department
From the Department of Microbiology and Biochemistry, were from the left, front: Dr Mariana Erasmus, Prof Martie Smit, Samantha McCarlie; back: Dr Carmien Tolmie; Samantha McCarlie, Prof Dirk Opperman, and Prof Robert Bragg. They believe publishing in high-impact factor journals reflects the quality of research delivered by the department.

Researchers in the Department of Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS) published their work in four impact factor eleven journals in 2019/2020, and a fifth was accepted for publication in a journal with impact factor twelve in 2020. 

Two articles were published in Nature Communications, one in Drug Resistance Updates and one in Natural Product Reports. A fifth article is already available as an accepted article at Angewandte Chemie. Researchers in the department work on very diverse topics, as reflected in the titles of these articles: ‘A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2’; ‘Native roles of Baeyer–Villiger monooxygenases in the microbial metabolism of natural compounds’; ‘The genome of a subterrestrial nematode reveals adaptations to heat’; ‘Molecular basis of bacterial disinfectant resistance’; and ‘CYP505E3 – a novel self‐sufficient ω‐7 in‐chain hydroxylase’.

Publishing in journals with a high impact factor is quite an achievement. Publishing in a journal with an impact factor of 3 is considered good and in most fields of study, publishing in journals with an impact factor of 10 or more is regarded as excellent. Impact factors are used to measure the importance of a journal by counting the number of times articles were cited in a certain time period. 

According to Prof Martie Smit, Head of the department, this is a reflection of the quality of research delivered by the department. “It is difficult and takes a lot of time and resources to publish in such high-impact journals.”

Contributing to their success in the department, is the work of their collaborators as well as the quality international postdoctoral researchers the department manages to attract with their emphasis on quality research.

Another highlight in the publication of these articles was that members of the department were corresponding authors of four of the five articles – meaning that the research was conducted in and driven from their laboratories, with UFS researchers taking primary responsibility for the preparation of the manuscripts and communicating with the editors of the journals.

Impacting society

Besides publishing in journals with high impact factors, these researchers are also making a difference to society. Prof Robert Bragg contributed to the study focusing on quality disinfectants. 

We are all aware of the danger of developing resistance to antibiotics. According to Prof Bragg, it is estimated that by 2050, 25 million people could be dying from antibiotic resistance-related bacterial infections per year. He says one of the best options to control diseases – not only bacterial diseases, but also viral diseases such as the Covid-19 outbreak – is good biosecurity and the use of good-quality disinfectants.

Researchers working on this study are trying to understand the development of resistance in bacteria to disinfectants. “This research group is currently investigating the ways in which bacteria become resistant to different high-quality disinfectants. The aim of this work is to discover new methods of resistance and then try to prevent bacteria from becoming resistant to commonly used disinfectants. One of the first aspects that needs investigation is to understand the methods of transfer of genetic information between bacteria. This work formed the basis of the review article written with master’s student Samantha McCarlie on transfer of genes that could code for disinfectant resistance in bacteria,” says Prof Bragg.

Studies about a nematode species discovered 1,3 km deep in a gold mine in Welkom and its ability to survive in extreme environments, made headlines about nine years ago. More extensive research has been performed on deep-space exploration of nematodes surviving extreme environments and were published in Nature Communications. Dr Mariana Erasmus, Assistant Director in the department and Technology Innovation Agency/UFS Saense Platform manager, says the study published in 2019 reveals these nematodes’ adaptation to heat and heat tolerance in an unusual ecosystem isolated from the surface biosphere. More studies on this can help humans learn how to adapt to a warming climate. 

TIA is an agency of the Department of Science and Innovation.

Three of the articles are from the Biocatalysis and Structural Biology group of Prof Dirk Opperman, Prof Martie Smit, and Dr Carmien Tolmie. Biocatalysis is a form of green chemistry that aims to produce chemicals in an environmentally friendly and sustainable manner. The research of the group focuses on using enzymes (proteins performing specialised chemical reactions) to insert an oxygen atom at a specific position in a starting material. Such reactions are difficult to perform using purely organic chemistry. 

The end products are value-added compounds of interest to, among others, the flavour and fragrance industry, which place a high premium on natural products. The work on the novel in‐chain hydroxylase was also patented internationally, because it can be used for the synthesis of a valuable flavour compound.
 
More to come

Besides the commitment of the team in Microbiology, it took multiple institutions, dedicated postdoctoral students, as well as time and money to publish this number of articles in high-impact journals in just over a year. With its 100-plus researchers varying from student researchers to NRF-rated scientists, everyone in the Department of Microbial, Biochemical and Food Biotechnology strives to produce high-quality research. 

And they promise, there is more to come. Watch this space …

News Archive

UFS Faculty of Health Sciences opens student residence in Trompsburg
2017-07-06

Description: Trompsburg read more Tags: Trompsburg read more

Official unveiling of the memorial plaque by
Prof Gert van Zyl, Dean of the Faculty of Health Sciences,
and Prof Francis Petersen, Rector and Vice-Chancellor
of the University of the Free State.
Photo: Charl Devenish

The University of the Free State’s (UFS) Faculty of Health Sciences has, as part of its commitment to student and community development, established a student residence in the town of Trompsburg in the Kopanong Local Municipality. The faculty officially opened the Rural Community Initiative and student residence in June 2017. The newly developed student residence has 10 apartments which could each accommodate six individuals.  A housemaster resides on the premises and acts as manager of the facility.  All areas of the residence are Wi-Fi covered and it has a 24-hour security service.

Importance of the residence
The goal of the Kopanang le fodise – Unite to heal programme is to develop a community-centred collaborative framework for sustainable, holistic healthcare and social development which is incorporated in the curricula of the faculty. During 2016, a total of 324 fourth-year students have each spent at least a week in primary healthcare facilities on a Community Based Education and Inter-Professional Education platform in Trompsburg and Springfontein in the Kopanong Municipality.

“This programme was commissioned to fulfil a specific goal. We are connecting our students with the community. The support of everyone coming together caused this to move from being just a spark, to a blaze. This is all our project,” said Dr René Botha, coordinator for Community-based Education and Rural Health in the faculty.

Community outreach a priority
“This is an innovative project that has been able to bring health and health-related issues to the community. One of the UFS’ three focus areas is community engagement. This project is primarily focused on serving the community, but also on the academic element, which is student development,” said Prof Francis Petersen, Rector and Vice-Chancellor of the UFS.

Prof Petersen commended the project on being the first of its kind in the South African Health Sciences sector. The platform will also be used for research purposes that will enrich the sector. Prof Petersen challenged the Kopanong community to give their input by answering two questions: What is the UFS good at? What is the UFS good for?

Reaching for the stars
“I am a dreamer and I have to reach, and if I reach, I reach for the stars. Today we are very lucky, because we have grabbed that star,” said Prof Gert van Zyl, Dean of the UFS Faculty of Health Sciences.

Prof Van Zyl reminded the audience that they possess the power to change challenges into stars by approaching them with careful thought, planning, and motivation. Prof Van Zyl concluded by stating that the rural community initiative is for the community, and that the faculty is just the facilitators.

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