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13 March 2020 | Story Leonie Bolleurs | Photo Leonie Bolleurs
Team from the UFS Microbiology department
From the Department of Microbiology and Biochemistry, were from the left, front: Dr Mariana Erasmus, Prof Martie Smit, Samantha McCarlie; back: Dr Carmien Tolmie; Samantha McCarlie, Prof Dirk Opperman, and Prof Robert Bragg. They believe publishing in high-impact factor journals reflects the quality of research delivered by the department.

Researchers in the Department of Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS) published their work in four impact factor eleven journals in 2019/2020, and a fifth was accepted for publication in a journal with impact factor twelve in 2020. 

Two articles were published in Nature Communications, one in Drug Resistance Updates and one in Natural Product Reports. A fifth article is already available as an accepted article at Angewandte Chemie. Researchers in the department work on very diverse topics, as reflected in the titles of these articles: ‘A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2’; ‘Native roles of Baeyer–Villiger monooxygenases in the microbial metabolism of natural compounds’; ‘The genome of a subterrestrial nematode reveals adaptations to heat’; ‘Molecular basis of bacterial disinfectant resistance’; and ‘CYP505E3 – a novel self‐sufficient ω‐7 in‐chain hydroxylase’.

Publishing in journals with a high impact factor is quite an achievement. Publishing in a journal with an impact factor of 3 is considered good and in most fields of study, publishing in journals with an impact factor of 10 or more is regarded as excellent. Impact factors are used to measure the importance of a journal by counting the number of times articles were cited in a certain time period. 

According to Prof Martie Smit, Head of the department, this is a reflection of the quality of research delivered by the department. “It is difficult and takes a lot of time and resources to publish in such high-impact journals.”

Contributing to their success in the department, is the work of their collaborators as well as the quality international postdoctoral researchers the department manages to attract with their emphasis on quality research.

Another highlight in the publication of these articles was that members of the department were corresponding authors of four of the five articles – meaning that the research was conducted in and driven from their laboratories, with UFS researchers taking primary responsibility for the preparation of the manuscripts and communicating with the editors of the journals.

Impacting society

Besides publishing in journals with high impact factors, these researchers are also making a difference to society. Prof Robert Bragg contributed to the study focusing on quality disinfectants. 

We are all aware of the danger of developing resistance to antibiotics. According to Prof Bragg, it is estimated that by 2050, 25 million people could be dying from antibiotic resistance-related bacterial infections per year. He says one of the best options to control diseases – not only bacterial diseases, but also viral diseases such as the Covid-19 outbreak – is good biosecurity and the use of good-quality disinfectants.

Researchers working on this study are trying to understand the development of resistance in bacteria to disinfectants. “This research group is currently investigating the ways in which bacteria become resistant to different high-quality disinfectants. The aim of this work is to discover new methods of resistance and then try to prevent bacteria from becoming resistant to commonly used disinfectants. One of the first aspects that needs investigation is to understand the methods of transfer of genetic information between bacteria. This work formed the basis of the review article written with master’s student Samantha McCarlie on transfer of genes that could code for disinfectant resistance in bacteria,” says Prof Bragg.

Studies about a nematode species discovered 1,3 km deep in a gold mine in Welkom and its ability to survive in extreme environments, made headlines about nine years ago. More extensive research has been performed on deep-space exploration of nematodes surviving extreme environments and were published in Nature Communications. Dr Mariana Erasmus, Assistant Director in the department and Technology Innovation Agency/UFS Saense Platform manager, says the study published in 2019 reveals these nematodes’ adaptation to heat and heat tolerance in an unusual ecosystem isolated from the surface biosphere. More studies on this can help humans learn how to adapt to a warming climate. 

TIA is an agency of the Department of Science and Innovation.

Three of the articles are from the Biocatalysis and Structural Biology group of Prof Dirk Opperman, Prof Martie Smit, and Dr Carmien Tolmie. Biocatalysis is a form of green chemistry that aims to produce chemicals in an environmentally friendly and sustainable manner. The research of the group focuses on using enzymes (proteins performing specialised chemical reactions) to insert an oxygen atom at a specific position in a starting material. Such reactions are difficult to perform using purely organic chemistry. 

The end products are value-added compounds of interest to, among others, the flavour and fragrance industry, which place a high premium on natural products. The work on the novel in‐chain hydroxylase was also patented internationally, because it can be used for the synthesis of a valuable flavour compound.
 
More to come

Besides the commitment of the team in Microbiology, it took multiple institutions, dedicated postdoctoral students, as well as time and money to publish this number of articles in high-impact journals in just over a year. With its 100-plus researchers varying from student researchers to NRF-rated scientists, everyone in the Department of Microbial, Biochemical and Food Biotechnology strives to produce high-quality research. 

And they promise, there is more to come. Watch this space …

News Archive

Grant encourages and enables more learners to enter into science-related studies and careers
2009-06-26

 
At the launch are, from the left, front: Consolation Mochusi, Graad 12 learner from Heatherdale Secondary School, Alexander Bergman, Grade 10 learner from Grey College Secondary School, Danél Prinsloo, Grade 11 learner from Eunice High School; middle: Ms Lea Koenig, Coordinator: ICT Laboratory of the Qwaqwa Campus, Prof. Daniela Coetzee-Manning, Director: CED; back: Ms Elna Fourie, Development Planner from SANRAL, Prof. Teuns Verschoor, Acting Rector of the UFS, Mr Cobus van Breda, Project Coordinator: CED and Mr Nazir Alli, Chief Executive Officer of SANRAL.
Photo: Stephen Collett


 

The University of the Free State’s (UFS) Centre for Education Development (CED) has this week launched a project on the Main Campus in Bloemfontein.
to enable and encourage more learners to enter into science-related studies and careers.

The grant of R4,5 million over a period of three years was made by the South African National Roads Agency Ltd (SANRAL). This week’s function was attended by the representatives of the sponsors and the UFS, as well as learners, parents, principals and Physical Sciences teachers of participating schools.

The grant will be utilised to foster a positive attitude towards Mathematics and Science amongst learners in the early school years as well as raising the knowledge and skills levels of learners in the Further Education and Training (FET) Phase. “This will be done through our Family Math and Family Science Programme for younger learners and through e-Education in Science and Mathematics for learners in the FET Phase,” said Mr Cobus van Breda, Project Coordinator at the CED.

About 330 selected Grade 10, 11 and 12 learners from 16 schools in the Free State are attending Physical Sciences and Mathematics sessions during weekdays at the ICT Laboratories on the Main and Qwaqwa Campuses of the UFS. In order to make provision for the needs of generation Y-learners (techno-clever generation), the project envisages to enhance their understanding of Science and Mathematics principles by utilising the advantages of ICTs (Information and Communication Technologies) during the sessions.

On average, learners attend four sessions per term, with one of the sessions a special event like visiting Boyden Observatory, departments at the UFS, etc. Learners will be exposed to about 36 sessions over the three years. Special attention to vocational guidance, in collaboration with the Unit for Prospective Students at the UFS, forms part of the support system of the programme to participating learners.

“Learning is a life-long experience and we must encourage our learners to grab this opportunity to learn more about important fields such as Mathematics and Science. It is a privilege for SANRAL to have this partnership with the CED and the university as it is an indication of our efforts to educate our youth,” said Mr Nazir Alli, Chief Executive Officer of SANRAL.

Mr Alli encouraged learners to grab the opportunity to learn and to make the field of science their career. “Science can be the foundation on which to build your career and this programme can assist you to reach your goal,” he said.

According to Prof. Teuns Verschoor, Acting Rector of the UFS, the SANRAL grant is a wise investment because it is an educational investment. “We cannot cut back on the investments we make in education and SANRAL’s investment in this programme is of benefit to schools and learners in the central region. Through this programme, its bursaries, various career opportunities and ongoing support of schools and universities SANRAL is making a huge contribution to promoting science-related studies and careers in our country,” he said.

Media Release
Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
26 June 2009

 

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