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13 March 2020 | Story Leonie Bolleurs | Photo Leonie Bolleurs
Team from the UFS Microbiology department
From the Department of Microbiology and Biochemistry, were from the left, front: Dr Mariana Erasmus, Prof Martie Smit, Samantha McCarlie; back: Dr Carmien Tolmie; Samantha McCarlie, Prof Dirk Opperman, and Prof Robert Bragg. They believe publishing in high-impact factor journals reflects the quality of research delivered by the department.

Researchers in the Department of Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS) published their work in four impact factor eleven journals in 2019/2020, and a fifth was accepted for publication in a journal with impact factor twelve in 2020. 

Two articles were published in Nature Communications, one in Drug Resistance Updates and one in Natural Product Reports. A fifth article is already available as an accepted article at Angewandte Chemie. Researchers in the department work on very diverse topics, as reflected in the titles of these articles: ‘A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2’; ‘Native roles of Baeyer–Villiger monooxygenases in the microbial metabolism of natural compounds’; ‘The genome of a subterrestrial nematode reveals adaptations to heat’; ‘Molecular basis of bacterial disinfectant resistance’; and ‘CYP505E3 – a novel self‐sufficient ω‐7 in‐chain hydroxylase’.

Publishing in journals with a high impact factor is quite an achievement. Publishing in a journal with an impact factor of 3 is considered good and in most fields of study, publishing in journals with an impact factor of 10 or more is regarded as excellent. Impact factors are used to measure the importance of a journal by counting the number of times articles were cited in a certain time period. 

According to Prof Martie Smit, Head of the department, this is a reflection of the quality of research delivered by the department. “It is difficult and takes a lot of time and resources to publish in such high-impact journals.”

Contributing to their success in the department, is the work of their collaborators as well as the quality international postdoctoral researchers the department manages to attract with their emphasis on quality research.

Another highlight in the publication of these articles was that members of the department were corresponding authors of four of the five articles – meaning that the research was conducted in and driven from their laboratories, with UFS researchers taking primary responsibility for the preparation of the manuscripts and communicating with the editors of the journals.

Impacting society

Besides publishing in journals with high impact factors, these researchers are also making a difference to society. Prof Robert Bragg contributed to the study focusing on quality disinfectants. 

We are all aware of the danger of developing resistance to antibiotics. According to Prof Bragg, it is estimated that by 2050, 25 million people could be dying from antibiotic resistance-related bacterial infections per year. He says one of the best options to control diseases – not only bacterial diseases, but also viral diseases such as the Covid-19 outbreak – is good biosecurity and the use of good-quality disinfectants.

Researchers working on this study are trying to understand the development of resistance in bacteria to disinfectants. “This research group is currently investigating the ways in which bacteria become resistant to different high-quality disinfectants. The aim of this work is to discover new methods of resistance and then try to prevent bacteria from becoming resistant to commonly used disinfectants. One of the first aspects that needs investigation is to understand the methods of transfer of genetic information between bacteria. This work formed the basis of the review article written with master’s student Samantha McCarlie on transfer of genes that could code for disinfectant resistance in bacteria,” says Prof Bragg.

Studies about a nematode species discovered 1,3 km deep in a gold mine in Welkom and its ability to survive in extreme environments, made headlines about nine years ago. More extensive research has been performed on deep-space exploration of nematodes surviving extreme environments and were published in Nature Communications. Dr Mariana Erasmus, Assistant Director in the department and Technology Innovation Agency/UFS Saense Platform manager, says the study published in 2019 reveals these nematodes’ adaptation to heat and heat tolerance in an unusual ecosystem isolated from the surface biosphere. More studies on this can help humans learn how to adapt to a warming climate. 

TIA is an agency of the Department of Science and Innovation.

Three of the articles are from the Biocatalysis and Structural Biology group of Prof Dirk Opperman, Prof Martie Smit, and Dr Carmien Tolmie. Biocatalysis is a form of green chemistry that aims to produce chemicals in an environmentally friendly and sustainable manner. The research of the group focuses on using enzymes (proteins performing specialised chemical reactions) to insert an oxygen atom at a specific position in a starting material. Such reactions are difficult to perform using purely organic chemistry. 

The end products are value-added compounds of interest to, among others, the flavour and fragrance industry, which place a high premium on natural products. The work on the novel in‐chain hydroxylase was also patented internationally, because it can be used for the synthesis of a valuable flavour compound.
 
More to come

Besides the commitment of the team in Microbiology, it took multiple institutions, dedicated postdoctoral students, as well as time and money to publish this number of articles in high-impact journals in just over a year. With its 100-plus researchers varying from student researchers to NRF-rated scientists, everyone in the Department of Microbial, Biochemical and Food Biotechnology strives to produce high-quality research. 

And they promise, there is more to come. Watch this space …

News Archive

Students excel in legal interpreting programme
2010-02-24

Prof. Ezekiel Moraka, Vice-Rector: External Relations at the UFS with one of the students who received a diploma.
Photo: Mangaliso Radebe


A success rate of 90% was achieved by the first group of 100 students that successfully completed the two-year Diploma in Legal Interpreting at the University of the Free State (UFS).

The group recently received their diplomas at the ceremony held on the Main Campus in Bloemfontein.

The programme, offered by the university’s Department of Afroasiatic Studies, Sign Language and Language Practice, in collaboration with the Department of Justice and Constitutional Development and Safety and Security Sector Education and Training Authority (SASSETA), is the only one of its kind in South Africa.

“The numbers that we are talking about here, if one looks at the needs of the country as such, is a small fraction,” said Advocate Simon Jiyane, Deputy Director General: Court Services in the Department of Justice.

“This is our first programme in collaboration with the UFS and I am hopeful it will lay a very solid foundation for other such programmes to follow.”

The diplomas were conferred by Prof. Ezekiel Moraka, Vice-Rector: External Relations at the UFS, on behalf of the Rector and Vice-Chancellor, Prof. Jonathan Jansen.

He urged the students to use their skills as qualified court interpreters in the context of the challenges that face South Africa such as HIV/Aids, racism, transformation, unemployment, poverty, job losses, and many other such challenges.

“This is the reality we are faced with, all of us,” he said. “It requires skilful and morally upright people to address it adequately and effectively. You are adding up to the number of skilful people in our country and that means you have a critical role to play.”

He said the UFS, as a societal structure, is equally affected by those challenges because of being accountable to and economically dependent on society.

He also urged the students to use their skills to make contributions to the processes of transformation that are underway at the UFS.

“For instance, the UFS as a national asset has to transform to that level of being a true national asset. We need your full participation in this process so that we can together ensure the relevance of this university as a true South African university,” he said.

Advocate Jiyane urged universities to also look at some of the initiatives that the government takes to improve service delivery. One such initiative is a pilot project focusing on the use of indigenous languages in courts.

“Its aim is to ensure that our courts begin to recognise all official languages in terms of conducting their business,” he said.

“It is our responsibility as a department that, through this project, we begin to build those languages so that they are on a par with the other languages that are being utilised in our courts.”

The department has permanently employed two of the students who received their diplomas, while one of them, Ms Nombulelo Esta Meki, was awarded a bursary by SASSETA to study for a BA in Legal Interpreting. Ms Meki was the top achiever of the programme with an average of 86%.

Media Release:
Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt@ufs.ac.za  
3 March 2010

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