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13 March 2020 | Story Leonie Bolleurs | Photo Leonie Bolleurs
Team from the UFS Microbiology department
From the Department of Microbiology and Biochemistry, were from the left, front: Dr Mariana Erasmus, Prof Martie Smit, Samantha McCarlie; back: Dr Carmien Tolmie; Samantha McCarlie, Prof Dirk Opperman, and Prof Robert Bragg. They believe publishing in high-impact factor journals reflects the quality of research delivered by the department.

Researchers in the Department of Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS) published their work in four impact factor eleven journals in 2019/2020, and a fifth was accepted for publication in a journal with impact factor twelve in 2020. 

Two articles were published in Nature Communications, one in Drug Resistance Updates and one in Natural Product Reports. A fifth article is already available as an accepted article at Angewandte Chemie. Researchers in the department work on very diverse topics, as reflected in the titles of these articles: ‘A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2’; ‘Native roles of Baeyer–Villiger monooxygenases in the microbial metabolism of natural compounds’; ‘The genome of a subterrestrial nematode reveals adaptations to heat’; ‘Molecular basis of bacterial disinfectant resistance’; and ‘CYP505E3 – a novel self‐sufficient ω‐7 in‐chain hydroxylase’.

Publishing in journals with a high impact factor is quite an achievement. Publishing in a journal with an impact factor of 3 is considered good and in most fields of study, publishing in journals with an impact factor of 10 or more is regarded as excellent. Impact factors are used to measure the importance of a journal by counting the number of times articles were cited in a certain time period. 

According to Prof Martie Smit, Head of the department, this is a reflection of the quality of research delivered by the department. “It is difficult and takes a lot of time and resources to publish in such high-impact journals.”

Contributing to their success in the department, is the work of their collaborators as well as the quality international postdoctoral researchers the department manages to attract with their emphasis on quality research.

Another highlight in the publication of these articles was that members of the department were corresponding authors of four of the five articles – meaning that the research was conducted in and driven from their laboratories, with UFS researchers taking primary responsibility for the preparation of the manuscripts and communicating with the editors of the journals.

Impacting society

Besides publishing in journals with high impact factors, these researchers are also making a difference to society. Prof Robert Bragg contributed to the study focusing on quality disinfectants. 

We are all aware of the danger of developing resistance to antibiotics. According to Prof Bragg, it is estimated that by 2050, 25 million people could be dying from antibiotic resistance-related bacterial infections per year. He says one of the best options to control diseases – not only bacterial diseases, but also viral diseases such as the Covid-19 outbreak – is good biosecurity and the use of good-quality disinfectants.

Researchers working on this study are trying to understand the development of resistance in bacteria to disinfectants. “This research group is currently investigating the ways in which bacteria become resistant to different high-quality disinfectants. The aim of this work is to discover new methods of resistance and then try to prevent bacteria from becoming resistant to commonly used disinfectants. One of the first aspects that needs investigation is to understand the methods of transfer of genetic information between bacteria. This work formed the basis of the review article written with master’s student Samantha McCarlie on transfer of genes that could code for disinfectant resistance in bacteria,” says Prof Bragg.

Studies about a nematode species discovered 1,3 km deep in a gold mine in Welkom and its ability to survive in extreme environments, made headlines about nine years ago. More extensive research has been performed on deep-space exploration of nematodes surviving extreme environments and were published in Nature Communications. Dr Mariana Erasmus, Assistant Director in the department and Technology Innovation Agency/UFS Saense Platform manager, says the study published in 2019 reveals these nematodes’ adaptation to heat and heat tolerance in an unusual ecosystem isolated from the surface biosphere. More studies on this can help humans learn how to adapt to a warming climate. 

TIA is an agency of the Department of Science and Innovation.

Three of the articles are from the Biocatalysis and Structural Biology group of Prof Dirk Opperman, Prof Martie Smit, and Dr Carmien Tolmie. Biocatalysis is a form of green chemistry that aims to produce chemicals in an environmentally friendly and sustainable manner. The research of the group focuses on using enzymes (proteins performing specialised chemical reactions) to insert an oxygen atom at a specific position in a starting material. Such reactions are difficult to perform using purely organic chemistry. 

The end products are value-added compounds of interest to, among others, the flavour and fragrance industry, which place a high premium on natural products. The work on the novel in‐chain hydroxylase was also patented internationally, because it can be used for the synthesis of a valuable flavour compound.
 
More to come

Besides the commitment of the team in Microbiology, it took multiple institutions, dedicated postdoctoral students, as well as time and money to publish this number of articles in high-impact journals in just over a year. With its 100-plus researchers varying from student researchers to NRF-rated scientists, everyone in the Department of Microbial, Biochemical and Food Biotechnology strives to produce high-quality research. 

And they promise, there is more to come. Watch this space …

News Archive

UFS intensifies its advocacy on humanity and solidarity to Japan
2011-03-08

Staff and students from our university, marching for humanity
Photo: Stephen Collett

Staff and students from the University of the Free State (UFS) representing various associations and student bodies, together with Kovsie supporters, braved the cold and wet weather yesterday (17 March) as they embarked on a march for humanity. This occurred just two days after an urgent meeting had been called by the Dean of Student Affairs, Mr Rudi Buys to create a platform for students to deliberate on mechanisms to be used in supporting Japan, which is facing immense challenges, thereby responding to their unfortunate current situation. It is also a day after the direct conversation between the UFS and the South African ambassador to Japan, Mr Gert Grobler, a Kovsie alumnus.

The visibly spirited group started their march from the Main Building on the UFS Main Campus in Bloemfontein. Within minutes the Callie Human Centre – assembly point for the participants – was occupied by students and staff members who arrived in their numbers, carrying banners with messages of support for Japan.

Modieyi Motholo, ISC Chairperson, read a memorandum in the presence of more than 300 students. “We, the community of the University of the Free State, as sons and daughters of South Africa and the world, by our very action in this march today, celebrate our shared humanity, declare our solidarity with the people of Japan, and join the movement to build a culture of Human Rights. We declare our commitment to the cause of human dignity and equality, and the promotion of human rights, non-racialism and non-sexism,” read the memorandum. 

“Japan is far; we shall never be able to take the entire Kovsie community there to assist the Japanese in rebuilding their homes. However, we can show our solidarity and raise an awareness for their unfortunate circumstances by our numbers,” Modieyi said.

Mr Buys admitted to being overwhelmed by the united Kovsie community he witnessed standing up for a cause they believed in. On receiving the memorandum on behalf of the UFS management, he stated: “There is a different and new set of values in our student community. We have the best students in the world, driven by a pioneering spirit aimed at building a new society. We have come so far in a short period of time. You deserve recognition as a student population.”

The march was also organised to declare the UFS’s support and solidarity for the people of Japan. The solidarity campaign has further been intensified with the establishment of committees comprising fundraising, research, marketing and awareness, spirituality and volunteers. Nida Jooste, the ISC Vice-Chairperson, said that the research committee was busy conducting a comprehensive study on how the UFS can be of assistance to the Japan. “With the report we will be able to design and implement programmes that will be aligned with the needs of the people of Japan. “In the meantime, we will carry out small projects that will keep the flame of solidarity burning on our campus,” she concluded.

Noticeable amongst the attendees were Mr John Samuels, the current Director of the International Institute for Studies in Race, Reconciliation and Social Justice.

 

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