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13 March 2020 | Story Leonie Bolleurs | Photo Leonie Bolleurs
Team from the UFS Microbiology department
From the Department of Microbiology and Biochemistry, were from the left, front: Dr Mariana Erasmus, Prof Martie Smit, Samantha McCarlie; back: Dr Carmien Tolmie; Samantha McCarlie, Prof Dirk Opperman, and Prof Robert Bragg. They believe publishing in high-impact factor journals reflects the quality of research delivered by the department.

Researchers in the Department of Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS) published their work in four impact factor eleven journals in 2019/2020, and a fifth was accepted for publication in a journal with impact factor twelve in 2020. 

Two articles were published in Nature Communications, one in Drug Resistance Updates and one in Natural Product Reports. A fifth article is already available as an accepted article at Angewandte Chemie. Researchers in the department work on very diverse topics, as reflected in the titles of these articles: ‘A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2’; ‘Native roles of Baeyer–Villiger monooxygenases in the microbial metabolism of natural compounds’; ‘The genome of a subterrestrial nematode reveals adaptations to heat’; ‘Molecular basis of bacterial disinfectant resistance’; and ‘CYP505E3 – a novel self‐sufficient ω‐7 in‐chain hydroxylase’.

Publishing in journals with a high impact factor is quite an achievement. Publishing in a journal with an impact factor of 3 is considered good and in most fields of study, publishing in journals with an impact factor of 10 or more is regarded as excellent. Impact factors are used to measure the importance of a journal by counting the number of times articles were cited in a certain time period. 

According to Prof Martie Smit, Head of the department, this is a reflection of the quality of research delivered by the department. “It is difficult and takes a lot of time and resources to publish in such high-impact journals.”

Contributing to their success in the department, is the work of their collaborators as well as the quality international postdoctoral researchers the department manages to attract with their emphasis on quality research.

Another highlight in the publication of these articles was that members of the department were corresponding authors of four of the five articles – meaning that the research was conducted in and driven from their laboratories, with UFS researchers taking primary responsibility for the preparation of the manuscripts and communicating with the editors of the journals.

Impacting society

Besides publishing in journals with high impact factors, these researchers are also making a difference to society. Prof Robert Bragg contributed to the study focusing on quality disinfectants. 

We are all aware of the danger of developing resistance to antibiotics. According to Prof Bragg, it is estimated that by 2050, 25 million people could be dying from antibiotic resistance-related bacterial infections per year. He says one of the best options to control diseases – not only bacterial diseases, but also viral diseases such as the Covid-19 outbreak – is good biosecurity and the use of good-quality disinfectants.

Researchers working on this study are trying to understand the development of resistance in bacteria to disinfectants. “This research group is currently investigating the ways in which bacteria become resistant to different high-quality disinfectants. The aim of this work is to discover new methods of resistance and then try to prevent bacteria from becoming resistant to commonly used disinfectants. One of the first aspects that needs investigation is to understand the methods of transfer of genetic information between bacteria. This work formed the basis of the review article written with master’s student Samantha McCarlie on transfer of genes that could code for disinfectant resistance in bacteria,” says Prof Bragg.

Studies about a nematode species discovered 1,3 km deep in a gold mine in Welkom and its ability to survive in extreme environments, made headlines about nine years ago. More extensive research has been performed on deep-space exploration of nematodes surviving extreme environments and were published in Nature Communications. Dr Mariana Erasmus, Assistant Director in the department and Technology Innovation Agency/UFS Saense Platform manager, says the study published in 2019 reveals these nematodes’ adaptation to heat and heat tolerance in an unusual ecosystem isolated from the surface biosphere. More studies on this can help humans learn how to adapt to a warming climate. 

TIA is an agency of the Department of Science and Innovation.

Three of the articles are from the Biocatalysis and Structural Biology group of Prof Dirk Opperman, Prof Martie Smit, and Dr Carmien Tolmie. Biocatalysis is a form of green chemistry that aims to produce chemicals in an environmentally friendly and sustainable manner. The research of the group focuses on using enzymes (proteins performing specialised chemical reactions) to insert an oxygen atom at a specific position in a starting material. Such reactions are difficult to perform using purely organic chemistry. 

The end products are value-added compounds of interest to, among others, the flavour and fragrance industry, which place a high premium on natural products. The work on the novel in‐chain hydroxylase was also patented internationally, because it can be used for the synthesis of a valuable flavour compound.
 
More to come

Besides the commitment of the team in Microbiology, it took multiple institutions, dedicated postdoctoral students, as well as time and money to publish this number of articles in high-impact journals in just over a year. With its 100-plus researchers varying from student researchers to NRF-rated scientists, everyone in the Department of Microbial, Biochemical and Food Biotechnology strives to produce high-quality research. 

And they promise, there is more to come. Watch this space …

News Archive

UFS first to mechanise agricultural technique
2006-05-09

    

Small farmers from Thaba `Nchu were the biggest group attending the farmers day at the UFS Paradys experimental farm.  From the left are Mr David Motlhale (a small farmer from Thaba 'Nchu), Prof Leon van Rensburg (lecturer at the UFS Department of Soil, Crop and Climate Sciences and project leader), Mr Nhlonipho Nhlabatsi (Agricultural Research Council, Glen), Ms Meisie Mthethwa (small farmer from Bloemspruit).  In front is Mr Patrick Molatodi (chairperson of the Tswelopele Small Farmer Association).
 

 

Some of the participants of the farmers day at the UFS Paradys experimental farm were from the left Prof Leon van Rensburg (lecturer at the UFS Department of Soil, Crop and Climate Sciences and project leader, Mr Patrick Molatodi (chairperson of the Tswelopele Small Farmers Association) and Prof Herman van Schalkwyk (Dean: UFS Faculty of Natural and Agricultural Sciences).

UFS first tertiary institution in world to mechanise agricultural technique
The University of the Free State (UFS) is the first tertiary institution in the world to mechanise the in-field rain water harvesting technique on a commercial scale.

The technique was recently demonstrated to about 100 small farmers at the UFS Paradys experimental farm outside Bloemfontein. 

“With this technique rain water is channeled to the plant and in this way food security is increased.  The advantage of the technique for commercial farmers lies in the reduced cultivation of land.  Small farmers will benefit from this because they can now move out into the fields and away from farming in their back yards,” says Prof Leon van Rensburg, lecturer at the UFS Department of Soil, Crop and Climate Sciences and project leader.    

Rain water harvesting is an antique concept that was used by communities before the birth of Christ.  In South Africa the technique is mainly used in the plots of small farmers where they make surface structures by hand. 

"The technique is also used for the first time by the UFS on commercial scale by means of the cultivation of a summer crop on 100 ha at the Paradys experimental farm,” says Prof Leon van Rensburg,

Of the farmers who attended the farmers day most represented about 42 rural communities in the vicinity of Thaba ‘Nchu.  A group of seven from KwaZulu-Natal also attended the proceedings.  These small farmers can for example apply this technique successfully on the 250-300 ha communal land that is available in the Thaba ‘Nchu area. 

The project is funded by the UFS and the National Research Foundation (NRF) and the farmers’ day was funded by the Water Research Commission.   

Media release
Issued by: Lacea Loader
Media Representative
Tel:   (051) 401-2584
Cell:  083 645 2454
E-mail:  loaderl.stg@mail.uovs.ac.za
9 May 2006

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