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13 March 2020 | Story Leonie Bolleurs | Photo Leonie Bolleurs
Team from the UFS Microbiology department
From the Department of Microbiology and Biochemistry, were from the left, front: Dr Mariana Erasmus, Prof Martie Smit, Samantha McCarlie; back: Dr Carmien Tolmie; Samantha McCarlie, Prof Dirk Opperman, and Prof Robert Bragg. They believe publishing in high-impact factor journals reflects the quality of research delivered by the department.

Researchers in the Department of Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS) published their work in four impact factor eleven journals in 2019/2020, and a fifth was accepted for publication in a journal with impact factor twelve in 2020. 

Two articles were published in Nature Communications, one in Drug Resistance Updates and one in Natural Product Reports. A fifth article is already available as an accepted article at Angewandte Chemie. Researchers in the department work on very diverse topics, as reflected in the titles of these articles: ‘A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2’; ‘Native roles of Baeyer–Villiger monooxygenases in the microbial metabolism of natural compounds’; ‘The genome of a subterrestrial nematode reveals adaptations to heat’; ‘Molecular basis of bacterial disinfectant resistance’; and ‘CYP505E3 – a novel self‐sufficient ω‐7 in‐chain hydroxylase’.

Publishing in journals with a high impact factor is quite an achievement. Publishing in a journal with an impact factor of 3 is considered good and in most fields of study, publishing in journals with an impact factor of 10 or more is regarded as excellent. Impact factors are used to measure the importance of a journal by counting the number of times articles were cited in a certain time period. 

According to Prof Martie Smit, Head of the department, this is a reflection of the quality of research delivered by the department. “It is difficult and takes a lot of time and resources to publish in such high-impact journals.”

Contributing to their success in the department, is the work of their collaborators as well as the quality international postdoctoral researchers the department manages to attract with their emphasis on quality research.

Another highlight in the publication of these articles was that members of the department were corresponding authors of four of the five articles – meaning that the research was conducted in and driven from their laboratories, with UFS researchers taking primary responsibility for the preparation of the manuscripts and communicating with the editors of the journals.

Impacting society

Besides publishing in journals with high impact factors, these researchers are also making a difference to society. Prof Robert Bragg contributed to the study focusing on quality disinfectants. 

We are all aware of the danger of developing resistance to antibiotics. According to Prof Bragg, it is estimated that by 2050, 25 million people could be dying from antibiotic resistance-related bacterial infections per year. He says one of the best options to control diseases – not only bacterial diseases, but also viral diseases such as the Covid-19 outbreak – is good biosecurity and the use of good-quality disinfectants.

Researchers working on this study are trying to understand the development of resistance in bacteria to disinfectants. “This research group is currently investigating the ways in which bacteria become resistant to different high-quality disinfectants. The aim of this work is to discover new methods of resistance and then try to prevent bacteria from becoming resistant to commonly used disinfectants. One of the first aspects that needs investigation is to understand the methods of transfer of genetic information between bacteria. This work formed the basis of the review article written with master’s student Samantha McCarlie on transfer of genes that could code for disinfectant resistance in bacteria,” says Prof Bragg.

Studies about a nematode species discovered 1,3 km deep in a gold mine in Welkom and its ability to survive in extreme environments, made headlines about nine years ago. More extensive research has been performed on deep-space exploration of nematodes surviving extreme environments and were published in Nature Communications. Dr Mariana Erasmus, Assistant Director in the department and Technology Innovation Agency/UFS Saense Platform manager, says the study published in 2019 reveals these nematodes’ adaptation to heat and heat tolerance in an unusual ecosystem isolated from the surface biosphere. More studies on this can help humans learn how to adapt to a warming climate. 

TIA is an agency of the Department of Science and Innovation.

Three of the articles are from the Biocatalysis and Structural Biology group of Prof Dirk Opperman, Prof Martie Smit, and Dr Carmien Tolmie. Biocatalysis is a form of green chemistry that aims to produce chemicals in an environmentally friendly and sustainable manner. The research of the group focuses on using enzymes (proteins performing specialised chemical reactions) to insert an oxygen atom at a specific position in a starting material. Such reactions are difficult to perform using purely organic chemistry. 

The end products are value-added compounds of interest to, among others, the flavour and fragrance industry, which place a high premium on natural products. The work on the novel in‐chain hydroxylase was also patented internationally, because it can be used for the synthesis of a valuable flavour compound.
 
More to come

Besides the commitment of the team in Microbiology, it took multiple institutions, dedicated postdoctoral students, as well as time and money to publish this number of articles in high-impact journals in just over a year. With its 100-plus researchers varying from student researchers to NRF-rated scientists, everyone in the Department of Microbial, Biochemical and Food Biotechnology strives to produce high-quality research. 

And they promise, there is more to come. Watch this space …

News Archive

Kovsie community pledge to advance equality and eradicate racism
2015-04-15

Photo: Johan Roux

Photo Gallery 
Speech by JC van der Merwe

On Monday 13 April 2015, the University of the Free State drew a line in history. Staff and students united in a singular vision: equality.

Since March 2015, the Institute for Reconciliation and Social Justice, together with the SRC, has launched the No-to-Racism/Yes-to-Equality Campaign across all three campuses with tremendous success. This campaign has now reached a high point at which the Kovsie community pledge their commitment to entrenching a culture of equality at the university. The first pledge ceremony took place on 13 April 2015 at the Bloemfontein Campus. Kovsies thronged to place their inked thumbprints on pledge posters in an inspirational show of solidarity.

“The key to transformation,” Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS, said, “is putting yourself in the shoes of the other person.” When you look past yourself and acknowledge others’ experiences, the world starts to look different. A pledge, Prof Jansen continued, is a solemn promise – not only to stop bad behaviour, but to go forward resolutely with good behaviour. “You do not change a campus, you do not change a country, without being courageous,” Prof Jansen said.

The message from Mosa Leteane, President of the Student Representative Council (SRC), echoed the same belief. “Today,” Leteane said, “the UFS takes a bold and courageous step toward equality.” This new generation, which includes young people from all races, has started a new revolution. A generation that says no to discrimination and yes to equality. “We cannot afford to be ignorant or indifferent,” Leteane urged.

The remaining two campuses will also have an opportunity to publically pledge their support on the following days:
Qwaqwa Campus: Wednesday 15 April 2015
South Campus: Friday 17 April 2015

To enable the university to go beyond dialogues and consultation towards active decision-making, a University Assembly will be held on Tuesday 28 April 2015. The assembly will serve as a space for critical engagement among all university stakeholders to focus on issues such as symbols, policies, practices, and curriculum. Staff and students are encouraged to submit matters for discussion to JC van der Merwe (vdmjc@ufs.ac.za) before 22 April 2015.

The No-to-Racism/Yes-to-Equality Campaign is aligned with the declaration made by the UFS Council in November 2014, in which it states that “the Council of the University of the Free State believes very strongly in the human dignity, equality, and freedom of all people.”

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