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13 March 2020 | Story Leonie Bolleurs | Photo Leonie Bolleurs
Team from the UFS Microbiology department
From the Department of Microbiology and Biochemistry, were from the left, front: Dr Mariana Erasmus, Prof Martie Smit, Samantha McCarlie; back: Dr Carmien Tolmie; Samantha McCarlie, Prof Dirk Opperman, and Prof Robert Bragg. They believe publishing in high-impact factor journals reflects the quality of research delivered by the department.

Researchers in the Department of Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS) published their work in four impact factor eleven journals in 2019/2020, and a fifth was accepted for publication in a journal with impact factor twelve in 2020. 

Two articles were published in Nature Communications, one in Drug Resistance Updates and one in Natural Product Reports. A fifth article is already available as an accepted article at Angewandte Chemie. Researchers in the department work on very diverse topics, as reflected in the titles of these articles: ‘A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2’; ‘Native roles of Baeyer–Villiger monooxygenases in the microbial metabolism of natural compounds’; ‘The genome of a subterrestrial nematode reveals adaptations to heat’; ‘Molecular basis of bacterial disinfectant resistance’; and ‘CYP505E3 – a novel self‐sufficient ω‐7 in‐chain hydroxylase’.

Publishing in journals with a high impact factor is quite an achievement. Publishing in a journal with an impact factor of 3 is considered good and in most fields of study, publishing in journals with an impact factor of 10 or more is regarded as excellent. Impact factors are used to measure the importance of a journal by counting the number of times articles were cited in a certain time period. 

According to Prof Martie Smit, Head of the department, this is a reflection of the quality of research delivered by the department. “It is difficult and takes a lot of time and resources to publish in such high-impact journals.”

Contributing to their success in the department, is the work of their collaborators as well as the quality international postdoctoral researchers the department manages to attract with their emphasis on quality research.

Another highlight in the publication of these articles was that members of the department were corresponding authors of four of the five articles – meaning that the research was conducted in and driven from their laboratories, with UFS researchers taking primary responsibility for the preparation of the manuscripts and communicating with the editors of the journals.

Impacting society

Besides publishing in journals with high impact factors, these researchers are also making a difference to society. Prof Robert Bragg contributed to the study focusing on quality disinfectants. 

We are all aware of the danger of developing resistance to antibiotics. According to Prof Bragg, it is estimated that by 2050, 25 million people could be dying from antibiotic resistance-related bacterial infections per year. He says one of the best options to control diseases – not only bacterial diseases, but also viral diseases such as the Covid-19 outbreak – is good biosecurity and the use of good-quality disinfectants.

Researchers working on this study are trying to understand the development of resistance in bacteria to disinfectants. “This research group is currently investigating the ways in which bacteria become resistant to different high-quality disinfectants. The aim of this work is to discover new methods of resistance and then try to prevent bacteria from becoming resistant to commonly used disinfectants. One of the first aspects that needs investigation is to understand the methods of transfer of genetic information between bacteria. This work formed the basis of the review article written with master’s student Samantha McCarlie on transfer of genes that could code for disinfectant resistance in bacteria,” says Prof Bragg.

Studies about a nematode species discovered 1,3 km deep in a gold mine in Welkom and its ability to survive in extreme environments, made headlines about nine years ago. More extensive research has been performed on deep-space exploration of nematodes surviving extreme environments and were published in Nature Communications. Dr Mariana Erasmus, Assistant Director in the department and Technology Innovation Agency/UFS Saense Platform manager, says the study published in 2019 reveals these nematodes’ adaptation to heat and heat tolerance in an unusual ecosystem isolated from the surface biosphere. More studies on this can help humans learn how to adapt to a warming climate. 

TIA is an agency of the Department of Science and Innovation.

Three of the articles are from the Biocatalysis and Structural Biology group of Prof Dirk Opperman, Prof Martie Smit, and Dr Carmien Tolmie. Biocatalysis is a form of green chemistry that aims to produce chemicals in an environmentally friendly and sustainable manner. The research of the group focuses on using enzymes (proteins performing specialised chemical reactions) to insert an oxygen atom at a specific position in a starting material. Such reactions are difficult to perform using purely organic chemistry. 

The end products are value-added compounds of interest to, among others, the flavour and fragrance industry, which place a high premium on natural products. The work on the novel in‐chain hydroxylase was also patented internationally, because it can be used for the synthesis of a valuable flavour compound.
 
More to come

Besides the commitment of the team in Microbiology, it took multiple institutions, dedicated postdoctoral students, as well as time and money to publish this number of articles in high-impact journals in just over a year. With its 100-plus researchers varying from student researchers to NRF-rated scientists, everyone in the Department of Microbial, Biochemical and Food Biotechnology strives to produce high-quality research. 

And they promise, there is more to come. Watch this space …

News Archive

Graduates encouraged to emulate the greats
2016-07-06

Description: z 2016 Winter grads Tags: z 2016 Winter grads

The University of the Free State Winter Graduation ceremonies
took place on 29 and 30 June 2016 on the Bloemfontein Campus.

Photo: Johan Roux

Trevor Manuel and Max du Preez among the recipients of honorary doctorates at UFS graduation 

Take up the challenge, make things happen, and emulate the greats. This was the overwhelming theme of messages from speakers to graduates at the Winter Graduation ceremonies of the University of the Free State (UFS).

According to Prof Joel Samoff, Professor in Africa Studies at Stanford University (USA), the graduands are the “new generation of analysts, researchers, and practitioners”, and should “assume the responsibility for keeping your senior colleagues on a productive path.” Prof Samoff, who received an honorary doctorate from the UFS on 30 June 2016, was the guest speaker at the afternoon graduation ceremony on 29 June 2016.

The UFS awarded a total of 482 Master’s and doctoral degrees on 30 June 2016 – 53 doctorates and 429 Master’s degrees – in the Callie Human Centre on the Bloemfontein Campus. On 29 June 2016, diplomas were awarded in the School of Financial Planning Law, as well as certificates and diplomas in education on the South Campus.

“You are smarter
than you think.
Smarter than other
people think you
are, and smarter
than the country
thinks you are.”


Rise above South African standards


According to Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS, South Africans have become use to a low standard of human decency, entertainment, and academics. He encouraged the graduates to rise above it.

“You are smarter than you think. Smarter than other people think you are, and smarter than the country thinks you are.”

Make impact like honorary doctorates


Dr Khotso Mokhele, UFS Chancellor, asked the recipients of honorary doctorates, Prof Samoff, Max du Preez, Trevor Manuel and Dr Reuel Jethro Khoza, and of the two Chancellor’s medals, Antony Osler and Marguerite van der Merwe (née Osler), to face the graduates at the morning ceremony on 30 June 2016. “I challenge you to look at them and to emulate them,” he said. “May it transform you to be like them in 10, 15 or 20 years.”

Dr Mokhele thanks Prof Jansen as leader


Dr Mokhele made special mention of Prof Jansen, who will step down as Vice-Chancellor and Rector on 31 August 2016, as these were his last UFS graduations. He thanked Prof Jansen for his major contribution to transformation at the UFS. “You are not only a Vice-Chancellor, but also a project leader,” Dr Mokhele said.

 

Click here to see a photo gallery of the graduations.

Click here to see a list of distinctions and special awards.

 

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