Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
13 March 2020 | Story Leonie Bolleurs | Photo Leonie Bolleurs
Team from the UFS Microbiology department
From the Department of Microbiology and Biochemistry, were from the left, front: Dr Mariana Erasmus, Prof Martie Smit, Samantha McCarlie; back: Dr Carmien Tolmie; Samantha McCarlie, Prof Dirk Opperman, and Prof Robert Bragg. They believe publishing in high-impact factor journals reflects the quality of research delivered by the department.

Researchers in the Department of Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS) published their work in four impact factor eleven journals in 2019/2020, and a fifth was accepted for publication in a journal with impact factor twelve in 2020. 

Two articles were published in Nature Communications, one in Drug Resistance Updates and one in Natural Product Reports. A fifth article is already available as an accepted article at Angewandte Chemie. Researchers in the department work on very diverse topics, as reflected in the titles of these articles: ‘A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2’; ‘Native roles of Baeyer–Villiger monooxygenases in the microbial metabolism of natural compounds’; ‘The genome of a subterrestrial nematode reveals adaptations to heat’; ‘Molecular basis of bacterial disinfectant resistance’; and ‘CYP505E3 – a novel self‐sufficient ω‐7 in‐chain hydroxylase’.

Publishing in journals with a high impact factor is quite an achievement. Publishing in a journal with an impact factor of 3 is considered good and in most fields of study, publishing in journals with an impact factor of 10 or more is regarded as excellent. Impact factors are used to measure the importance of a journal by counting the number of times articles were cited in a certain time period. 

According to Prof Martie Smit, Head of the department, this is a reflection of the quality of research delivered by the department. “It is difficult and takes a lot of time and resources to publish in such high-impact journals.”

Contributing to their success in the department, is the work of their collaborators as well as the quality international postdoctoral researchers the department manages to attract with their emphasis on quality research.

Another highlight in the publication of these articles was that members of the department were corresponding authors of four of the five articles – meaning that the research was conducted in and driven from their laboratories, with UFS researchers taking primary responsibility for the preparation of the manuscripts and communicating with the editors of the journals.

Impacting society

Besides publishing in journals with high impact factors, these researchers are also making a difference to society. Prof Robert Bragg contributed to the study focusing on quality disinfectants. 

We are all aware of the danger of developing resistance to antibiotics. According to Prof Bragg, it is estimated that by 2050, 25 million people could be dying from antibiotic resistance-related bacterial infections per year. He says one of the best options to control diseases – not only bacterial diseases, but also viral diseases such as the Covid-19 outbreak – is good biosecurity and the use of good-quality disinfectants.

Researchers working on this study are trying to understand the development of resistance in bacteria to disinfectants. “This research group is currently investigating the ways in which bacteria become resistant to different high-quality disinfectants. The aim of this work is to discover new methods of resistance and then try to prevent bacteria from becoming resistant to commonly used disinfectants. One of the first aspects that needs investigation is to understand the methods of transfer of genetic information between bacteria. This work formed the basis of the review article written with master’s student Samantha McCarlie on transfer of genes that could code for disinfectant resistance in bacteria,” says Prof Bragg.

Studies about a nematode species discovered 1,3 km deep in a gold mine in Welkom and its ability to survive in extreme environments, made headlines about nine years ago. More extensive research has been performed on deep-space exploration of nematodes surviving extreme environments and were published in Nature Communications. Dr Mariana Erasmus, Assistant Director in the department and Technology Innovation Agency/UFS Saense Platform manager, says the study published in 2019 reveals these nematodes’ adaptation to heat and heat tolerance in an unusual ecosystem isolated from the surface biosphere. More studies on this can help humans learn how to adapt to a warming climate. 

TIA is an agency of the Department of Science and Innovation.

Three of the articles are from the Biocatalysis and Structural Biology group of Prof Dirk Opperman, Prof Martie Smit, and Dr Carmien Tolmie. Biocatalysis is a form of green chemistry that aims to produce chemicals in an environmentally friendly and sustainable manner. The research of the group focuses on using enzymes (proteins performing specialised chemical reactions) to insert an oxygen atom at a specific position in a starting material. Such reactions are difficult to perform using purely organic chemistry. 

The end products are value-added compounds of interest to, among others, the flavour and fragrance industry, which place a high premium on natural products. The work on the novel in‐chain hydroxylase was also patented internationally, because it can be used for the synthesis of a valuable flavour compound.
 
More to come

Besides the commitment of the team in Microbiology, it took multiple institutions, dedicated postdoctoral students, as well as time and money to publish this number of articles in high-impact journals in just over a year. With its 100-plus researchers varying from student researchers to NRF-rated scientists, everyone in the Department of Microbial, Biochemical and Food Biotechnology strives to produce high-quality research. 

And they promise, there is more to come. Watch this space …

News Archive

Louzanne Coetzee heading for Paralympic Games in Rio
2016-08-02

Description: Louzanne Coetzee  Tags: Louzanne Coetzee

Louzanne Coetzee (left) from the University of the
Free State and her guide Khothatso Mokone, a former Kovsie,
will compete in the Paralympic Games in Rio de Janeiro,
Brazil, from 7 to 18 September 2016.
Photo: Rufus Botha

Her perseverance and faith. Faith in herself and her coaches, as well as her Christian faith. Rufus Botha says this is what makes the Paralympic athlete Louzanne Coetzee special. According to her coach, the 23-year-old star from the University of the Free State (UFS) is easy to work with. “Her work ethic is incredible. As coach, I actually have to stop her,” he jokes. “She does not like to rest.”

On 19 July 2016, Coetzee was included in South Africa’s Paralympic team for the Olympics in Rio de Janeiro, Brazil. She and her guide Khothatso Mokone, also a former Kovsie, were included in the team that will participate in Rio from 7 to 18 September 2016.

Sights still set on 2020 Olympics

In Brazil, Coetzee will compete in the T11 category in the 1 500 m. The blind athlete is also outstanding in the 800 m and 5 000 m, of which she is the world record holder, but these items do not feature at the Olympics.

Botha says Coetzee has her sights still set on the 2020 Paralympic Games in Tokyo, Japan. “Anything she achieves in Rio will actually be a bonus.” He says it was an achievement on its own to be included in the SA team among established athletes such as Arnu Fourie and Ilse (Hayes) Carstens.

CUADS super proud of record-breaker

“Anything she achieves in Rio
will actually be a bonus.”


“Louzanne is an absolute star and an example to so many Kovsie students,” says Martie Miranda, Head of the Centre for Universal Access and Disability Support (CUADS) at the UFS. “We are super proud of her.”

On 17 July 2016, Coetzee set a new Africa record (5:00:25) in the 1 500 m in Berlin. She will leave for Rio on 30 August 2016, with her heat taking place on 15 September 2016 and the finals on 17 September 2016.

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept