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13 March 2020 | Story Leonie Bolleurs | Photo Leonie Bolleurs
Team from the UFS Microbiology department
From the Department of Microbiology and Biochemistry, were from the left, front: Dr Mariana Erasmus, Prof Martie Smit, Samantha McCarlie; back: Dr Carmien Tolmie; Samantha McCarlie, Prof Dirk Opperman, and Prof Robert Bragg. They believe publishing in high-impact factor journals reflects the quality of research delivered by the department.

Researchers in the Department of Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS) published their work in four impact factor eleven journals in 2019/2020, and a fifth was accepted for publication in a journal with impact factor twelve in 2020. 

Two articles were published in Nature Communications, one in Drug Resistance Updates and one in Natural Product Reports. A fifth article is already available as an accepted article at Angewandte Chemie. Researchers in the department work on very diverse topics, as reflected in the titles of these articles: ‘A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2’; ‘Native roles of Baeyer–Villiger monooxygenases in the microbial metabolism of natural compounds’; ‘The genome of a subterrestrial nematode reveals adaptations to heat’; ‘Molecular basis of bacterial disinfectant resistance’; and ‘CYP505E3 – a novel self‐sufficient ω‐7 in‐chain hydroxylase’.

Publishing in journals with a high impact factor is quite an achievement. Publishing in a journal with an impact factor of 3 is considered good and in most fields of study, publishing in journals with an impact factor of 10 or more is regarded as excellent. Impact factors are used to measure the importance of a journal by counting the number of times articles were cited in a certain time period. 

According to Prof Martie Smit, Head of the department, this is a reflection of the quality of research delivered by the department. “It is difficult and takes a lot of time and resources to publish in such high-impact journals.”

Contributing to their success in the department, is the work of their collaborators as well as the quality international postdoctoral researchers the department manages to attract with their emphasis on quality research.

Another highlight in the publication of these articles was that members of the department were corresponding authors of four of the five articles – meaning that the research was conducted in and driven from their laboratories, with UFS researchers taking primary responsibility for the preparation of the manuscripts and communicating with the editors of the journals.

Impacting society

Besides publishing in journals with high impact factors, these researchers are also making a difference to society. Prof Robert Bragg contributed to the study focusing on quality disinfectants. 

We are all aware of the danger of developing resistance to antibiotics. According to Prof Bragg, it is estimated that by 2050, 25 million people could be dying from antibiotic resistance-related bacterial infections per year. He says one of the best options to control diseases – not only bacterial diseases, but also viral diseases such as the Covid-19 outbreak – is good biosecurity and the use of good-quality disinfectants.

Researchers working on this study are trying to understand the development of resistance in bacteria to disinfectants. “This research group is currently investigating the ways in which bacteria become resistant to different high-quality disinfectants. The aim of this work is to discover new methods of resistance and then try to prevent bacteria from becoming resistant to commonly used disinfectants. One of the first aspects that needs investigation is to understand the methods of transfer of genetic information between bacteria. This work formed the basis of the review article written with master’s student Samantha McCarlie on transfer of genes that could code for disinfectant resistance in bacteria,” says Prof Bragg.

Studies about a nematode species discovered 1,3 km deep in a gold mine in Welkom and its ability to survive in extreme environments, made headlines about nine years ago. More extensive research has been performed on deep-space exploration of nematodes surviving extreme environments and were published in Nature Communications. Dr Mariana Erasmus, Assistant Director in the department and Technology Innovation Agency/UFS Saense Platform manager, says the study published in 2019 reveals these nematodes’ adaptation to heat and heat tolerance in an unusual ecosystem isolated from the surface biosphere. More studies on this can help humans learn how to adapt to a warming climate. 

TIA is an agency of the Department of Science and Innovation.

Three of the articles are from the Biocatalysis and Structural Biology group of Prof Dirk Opperman, Prof Martie Smit, and Dr Carmien Tolmie. Biocatalysis is a form of green chemistry that aims to produce chemicals in an environmentally friendly and sustainable manner. The research of the group focuses on using enzymes (proteins performing specialised chemical reactions) to insert an oxygen atom at a specific position in a starting material. Such reactions are difficult to perform using purely organic chemistry. 

The end products are value-added compounds of interest to, among others, the flavour and fragrance industry, which place a high premium on natural products. The work on the novel in‐chain hydroxylase was also patented internationally, because it can be used for the synthesis of a valuable flavour compound.
 
More to come

Besides the commitment of the team in Microbiology, it took multiple institutions, dedicated postdoctoral students, as well as time and money to publish this number of articles in high-impact journals in just over a year. With its 100-plus researchers varying from student researchers to NRF-rated scientists, everyone in the Department of Microbial, Biochemical and Food Biotechnology strives to produce high-quality research. 

And they promise, there is more to come. Watch this space …

News Archive

Democracy and political tolerance truly thrive during Qwaqwa Campus SRC elections
2016-09-16

Description: 2017 SR Qwaqwa  Tags: 2017 SR Qwaqwa

The newly-elected SRC President of the Qwaqwa
Campus, Njabulo Mwali (left), being congratulated
by his predecessor, Paseka Sikhosana.
Ph
oto: Thabiso Gamede

Voter turnout during the recent SRC elections among the best in the country at over 60%

The 2016-2017 Qwaqwa Campus SRC elections have once again proven that democracy and political tolerance are truly thriving on the Qwaqwa Campus. This was evidenced by the calm surrounding the highly contested elections ever.

According to Mandla Ndlangamandla, Electoral Committee Chairperson, this year’s elections were highly contentious, yet with a high level of tolerance.

"We only had two political structures, namely the South African Democratic Student Movement (Sadesmo) and the South African Student Congress (Sasco), but the level of engagement was really commendable,” he said.

“Of the 4 200 registered students on campus, more than 2 500 cast their votes in their quest to influence student leadership and governance to advance student aspirations," said Ndlangamandla during the handover ceremony.

In accepting the leadership baton from his predecessor, Paseka Sikhosana, the new President, Njabulo Mwali, said his immediate goal was to unite all students behind the new leadership.

In acknowledging the role student governance can play in developing the campus, the Acting Campus Principal, Teboho Manchu, said the campus was proud to have a student leadership that would always keep the interests of their constituency on top of their agenda.

“We will definitely work hand-in-hand with the new student government. In case of any disagreements, please note that you have the right to take up any such matters with the top management of the university in order to advance the entire student body,” he added.

The 2016-2017 Qwaqwa Campus SRC is as follows:

LIST OF SRC MEMBERS 2016-2017

Elective Portfolios

 

Name and Surname

Portfolio

Njabulo Mwali

President General

Siyabonga Ngubo

Deputy President

Joy Mapule Motloung

Secretary General

Bongela Nyandeni

Treasurer General

Mpumelelo Tshabalala

Politics and Transformation

Nomcebo Mqushulu

Media and Publicity

Ntokozo Michael Masiteng

Student Development and Environmental Affairs

   

Ex Officio Portfolios

 

Khulani Mhlongo

Arts and Culture

Polaki Mazibuko

Academic Affairs

Ntokozo Mbali Thango

Sports Affairs

Motlatsi Lisley Lebona

Religious Affairs

Sandile Ntamane

Residence Affairs

Itumeleng Chefter

RAG Comm. and Dialogue

Thulebona Thomas Khumalo

Off-campus

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