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A Virtual celebration of Africa Month

22 May 2020 | Story Nitha Ramnath

A Virtual celebration of Africa Month

On 25 May 2020, Africa will celebrate the 57th anniversary of the founding of the Organisation of African Unity. A central tenet of the organisation, which was the predecessor of the African Union, is African solidarity. Member states undertook to coordinate and intensify their cooperation and efforts to achieve a better life for the people of Africa. The University of the Free State (UFS) has a long tradition of commemorating Africa Day and the ideas underpinning it. Every year, diverse events aimed at advancing African unity and solidarity take place during Africa Month – traditionally, the highlight is the Africa Day Memorial Lecture hosted by the University's Centre for Gender and Africa Studies.

This year, celebrating African unity through significant events involving the physical presence of a large number of people, will likely be impossible. COVID-19 is ravaging the world and Africa may become one of the world regions worst affected by the consequences of the virus. Social distancing may be difficult to achieve in a continent with densely populated urban centres that often feature large informal settlements. Besides, the economies of African nations are not as robust as those of other world regions. The challenge that Africa is facing, appears to be one that can only be mastered by its people acting in solidarity and unity. The continent has already developed an Africa Joint Continental Strategy for COVID-19 Outbreak to combat the virus, and an Africa Taskforce for Coronavirus has been established. The ideas of African togetherness and the underpinning philosophy of Ubuntu may be critical for strengthening African solidarity at a time when it may be more relevant than ever.

The commemoration of Africa Day takes a different theme each year. This year, the UFS 2020 Africa Month celebrations will take a virtual format, with the theme of ‘Africa together forever’ underpinned by the COVID-19 global pandemic. The theme is particularly significant considering the context of the African continent; and only through the demonstration of solidarity and unity can Africa overcome the challenges of the global pandemic.

The University will host a variety of cultural and intellectual contributions on the dedicated UFS virtual Africa Month website. On Africa Day (25 May 2020), a virtual Africa Day function, which will be posted on the website, will conclude the Africa Month commemorations.

The diverse contributions to the 2020 virtual Africa Month activities will highlight the University’s commitment towards creating a diverse, challenging intellectual environment. The UFS strives as a research-led university, to provide an environment in which new ideas are incubated and debated; contributing towards its transformation process and African unity.

News Archive

UFS study on cell development in top international science journal

2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
18 September 2008

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