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16 Days of Activism in Lockdown

25 November 2020 Photo Anja Aucamp

Prof Colin Chasi outside Centenary Complex (Anja Aucamp) — Prof Colin Chasi is the Director of the Unit for Institutional Change and Social Justice at the UFS.

The 2020 programme around the 16 Days of Activism against Gender-Based Violence will be novel in that it will be run online. “For each person to register and log into the various programmes is a small step. But each such step makes a big difference by saying that the lives of survivors matter and by underscoring that gender-based violence will not be tolerated at the UFS,” says Prof Colin Chasi, Director of the Unit for Institutional Change and Social Justice (UICSJ) at the UFS.

Women and girl children have experienced increased violence in the time of the COVID-19 lockdown, states the UN Secretary General's report, Shared Responsibility, Global Solidarity: Responding to the socio-economic impacts of COVID-19. In South Africa, there have been reports of a scourge of rape in the post-school education and training sector. At the UFS, these developments have challenged the Gender Equity and Anti-Discrimination Office (GEADO) to come up with innovative online interventions.

In 2019, the University of the Free State (UFS) established the Unit for Institutional Change and Social Justice (formerly known as the Institute for Reconciliation and Social Justice, founded in 2009). The GEADO was launched on 8 April 2019 and was incorporated into the unit to run a cross-functional Sexual Assault Response Team (SART) and to organise programmes that combat gender-based violence and other forms of gender injustice.

“We have been able to offer our services with minimal disruption throughout the year,” says Geraldine Lengau, a Bloemfontein Campus-based GEADO officer.

“Most exciting for us is that we have taken the lockdown as an opportunity to expand the scope of ways in which we engage with students and communities,” notes Chelepe Mocwana, a GEADO officer on the South Campus. “GEADO has offered a number of online webinars and seminars, and the university has made telephonic services available that support, for example, the mental health of survivors of sexual violence.”

“On the Qwaqwa Campus, where we still have some problems with consistent access to data networks, we were pleased to see that our webinars have been well-subscribed to by students and staff members,” reports Siya Magayana, who is the GEADO officer on this campus.

“Each such step makes a big difference by saying that the
lives of survivors matter and by underscoring that
gender-based violence will not be tolerated at the UFS.”
—Prof Colin Chasi, Director of the UICSJ.

Since 1991, activists around the world have annually coordinated activities around the 16 Days of Activism against Gender-Based Violence. The 16 days of activism begin on 25 November, the International Day for the Elimination of Violence against Women, and run until 10 December, which is International Human Rights Day. The start and end dates signify that the fight to eliminate violence against women advances human rights for all.

Activities to mark the 16 Days of Activism against Gender-Based Violence will be advertised on various UFS communication platforms.

News Archive

UFS study on cell development in top international science journal

2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
18 September 2008

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