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13 November 2020 | Story Charlene Stanley | Photo Supplied
Dr Innocent Dande, UFS ISG scholar, has been named the 2021 winner of the JSAS Colin Murray Prize for his research on food politics in Zimbabwe.

Dr Innocent’s Dande’s research on the everyday food struggles experienced by residents of poor suburbs in Harare, Zimbabwe, has earned him a coveted research prize from the London-based Journal of Southern African Studies (JSAS) – the leading international journal in its field.   

Start of extended book project
“Winning this award means a great deal for my career plans, especially as I am planning to come up with an extended book project that looks at working classes’ eating habits and foodscapes, or the geographies of food, cooking and eating in lower class suburbs,” says an excited Dr Dande.  His aim is to write a sensorial history of how the working classes ate and enjoyed food in Zimbabwean cities between 1980 and 2019.
“One advantage is that this prize provides me with funding to carry out research. If the JSAS is satisfied with the outcome, their tradition is to publish it,” he says.

Not deterred by lockdown
Dr Dande arrived at the UFS at the same time the COVID-19 lockdown was announced, which saw many of his colleagues hastily returning to their home countries. His decision to stay indirectly led to his application.
“I was spending so much of my time in my room at Kovsie Inn during Level one of the lockdown. Applying for this grant was a way of dealing with the boredom that comes with locking oneself in for too long,” he explains.  
His application was titled, Cooking, the crisis and cuisines: household economies and food politics in Harare (Zimbabwe), 1997-2020, with much of his research focusing on everyday issues affecting ordinary people, in contrast to “high politics and many other topics that ordinarily shout for more attention.” His aim is to write a social history of the Zimbabwean crisis, focusing on “mundane issues such as the cooking and eating of food.” 

Colin Murray Prize background
Colin Murray was a sociologist, anthropologist, and political economist who passed away in October 2013. He taught at various universities in the UK and South Africa and had a special interest in family histories. Carrying a purse of £2 500, the Colin Murray Prize is awarded to an applicant who is within two years of completing his or her PhD, and is meant to assist the winner in engaging in original research in Murray’s fields of interest. 

ISG an intellectually enriching environment
The COVID-19 pandemic may have restricted physical interactions with colleagues, but Dr Dande says he still found the International Studies Group (ISG) an intellectually enriching place. 
“The ISG continued to hold regular and interesting Zoom seminars. Many of my colleagues have also won very prestigious prizes and are in different stages of completing their various projects. Many others have also published in the same journal (JSAS) and many other high-impact journals.” 
He highly values the generous professional advice from his fellow researchers, as well as the input and feedback of ISG Head, Prof Ian Phimister.
“The ISG has shown me that it is possible to dream big and to even contemplate applying for jobs anywhere in the world and not just in Southern Africa,” says Dr Dande.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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