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05 November 2020 | Story Andre Damons | Photo Supplied
Heinrich Janse van Rensburg’s is a 5th year medical student from the University of the Free State whose photo was highly commended at the Imperial College London’s Global Creative Competition: Medical Student Responses to COVID-19.

A late-night photo taken through a window at the Pelonomi hospital by a final-year medical student from the University of the Free State (UFS) was highly commended at the first Global Creative Competition: Medical Student Responses to COVID-19.

The competition, held by the Imperial College London, received more than 600 entries from more than 52 countries. The competition was held to bring together the global community of medical students to submit their creative responses to COVID-19 and to provide a platform for them to reflect on their personal and professional experiences during this challenging time.

Medical students from around the world could enter in two categories; visual and literary, and the winners were announced during a Global Awards Ceremony on 14 October.

Meaning behind the photo

Heinrich Janse van Rensburg’s late -night photo highlights the economic inequality that persists in South Africa. The photo was taken from the Pelonomi Hospital which is located in Heidedal, Bloemfontein, and shows the old, forsaken Dutch Reformed church in the foreground, shacks in the background with smoke billowing from the dwellings, where up to six people live in one room trying to stay warm during winter. They are built so close to each other that there can be no talk of effective social distancing.

According to Janse van Rensburg the theme of inequality in the South African milieu is further shown in the striking contrast between light and dark in the picture. “And now, with the COVID-19 pandemic placing a massive burden on an already struggling healthcare system the inequality is even more visible,” says Janse van Rensburg.

 

Janse van Rensburg’s late-night photo taken from the Pelonomi Hospital in Heidedal, Bloemfontein, shows the economic inequality that persists in South Africa. The photo was highly commended at the Imperial College London’s Global Creative Competition for Medical Student Responses to COVID-19.


A little shocked 

He was a little shocked when he heard his photograph was highly commended. Janse van Rensburg says: “Imperial College London is a big institution and being an international competition I did not really expect a lot. There were participants from over 52 countries, and having seen some of the works that were submitted it feels special to be one of the students being noticed.”

Janse van Rensburg, who has never considered doing art, heard about the competition through the Faculty of Health Sciences platforms during lockdown level 5. He saw it as an opportunity to reflect, which has become even more imperative in times like these.

He says he does not go searching for art, but “notices” it from being conscious – something he thinks is important in medicine and life.

Value of creativity in promoting mental well-being

Dr Lynette van der Merwe, undergraduate medical programme director, School of Clinical Medicine, congratulated Janse van Rensburg, saying this commendation in an international competition underscores his talent and the value of creativity in promoting mental well-being.

“Heinrich’s artwork and showcase precisely what we aspire to develop in our exceptional UFS doctors-in-training: a professional with self-awareness, empathy and humanity.

“We initiated a Mental Health Awareness initiative and art competition in the School of Clinical Medicine in 2018 to promote creative expression as a means of supporting students’ mental health. Heinrich has won awards with his creative contributions every year, exhibiting his imaginative ability.”

Surgery and photography

Janse van Rensburg says he has always loved beautiful things and the meaning people attach to art is a good way to communicate that. He has applied for an internship at the Mitchells Plain hospital for when he completes his studies at the end of this year and is thinking of specialising in reconstructive or pediatrics surgery. Besides that, he would like to tap into his creative side and continue with the photography.

  • Watch the video of the winners here

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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