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05 November 2020 | Story Thabo Kessah
Prof Moffett’s latest offering collates hundreds of mountain research material into one accessible reference book.

Prof Rodney Moffett recently published a new book focusing on various scientific articles published between 1808 and 2019. The book, A Scientific Bibliography of the Drakensberg, Maloti and Adjacent Lowlands, has 534 pages and covers material appearing in accredited journals, plus unpublished but traceable reports, documents, presentations, and dissertations.

“The scientific articles range from palaeobotany with 17 entries, to rock art with 502 entries, as well as 252 theses and dissertations,” said Prof Moffett.

He said it took 18 months to compile the book, typing the manuscript himself – mostly at night.

In the foreword, Dr Ralph Clark, Director: Afromontane Research Unit (ARU), says: “This bibliography is a labour of love, and will inspire a new generation to take up the baton for excellent research in this fantastic mountain system. We are proud to publish this under the ARU banner as a contribution to growing and consolidating mountain-passionate relationships in Southern Africa, and to encourage our journey towards developing a holistic understanding and sustainable use of these iconic mountain landscapes.” 

Other books

Prof Moffett is an honorary research fellow in the Department of Plant Sciences at the University of the Free State, and an associate of the Afromontane Research Unit on the UFS Qwaqwa Campus. He was previously Professor of Botany on the Qwaqwa Campus when it was part of the University of the North, retiring in 2000. Since then, he has remained active, publishing scholarly works on ethnobotany and other natural history subjects.

His four recent books, also published by Sun Press, are: Sesotho Plant and Animal Names and Plants used by the Basotho (2010), A Biographical Dictionary of Contributors to the Natural History of the Free State and Lesotho (2014), Basotho Medicinal Plants – Meriana ya Dimela tsa Basotho (2016), and A Field Guide to the Clarens Village Conservancy (2018). A second revised edition of Meriana ya Dimela tsa Basotho – 

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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