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05 November 2020 | Story Thabo Kessah
Prof Moffett’s latest offering collates hundreds of mountain research material into one accessible reference book.

Prof Rodney Moffett recently published a new book focusing on various scientific articles published between 1808 and 2019. The book, A Scientific Bibliography of the Drakensberg, Maloti and Adjacent Lowlands, has 534 pages and covers material appearing in accredited journals, plus unpublished but traceable reports, documents, presentations, and dissertations.

“The scientific articles range from palaeobotany with 17 entries, to rock art with 502 entries, as well as 252 theses and dissertations,” said Prof Moffett.

He said it took 18 months to compile the book, typing the manuscript himself – mostly at night.

In the foreword, Dr Ralph Clark, Director: Afromontane Research Unit (ARU), says: “This bibliography is a labour of love, and will inspire a new generation to take up the baton for excellent research in this fantastic mountain system. We are proud to publish this under the ARU banner as a contribution to growing and consolidating mountain-passionate relationships in Southern Africa, and to encourage our journey towards developing a holistic understanding and sustainable use of these iconic mountain landscapes.” 

Other books

Prof Moffett is an honorary research fellow in the Department of Plant Sciences at the University of the Free State, and an associate of the Afromontane Research Unit on the UFS Qwaqwa Campus. He was previously Professor of Botany on the Qwaqwa Campus when it was part of the University of the North, retiring in 2000. Since then, he has remained active, publishing scholarly works on ethnobotany and other natural history subjects.

His four recent books, also published by Sun Press, are: Sesotho Plant and Animal Names and Plants used by the Basotho (2010), A Biographical Dictionary of Contributors to the Natural History of the Free State and Lesotho (2014), Basotho Medicinal Plants – Meriana ya Dimela tsa Basotho (2016), and A Field Guide to the Clarens Village Conservancy (2018). A second revised edition of Meriana ya Dimela tsa Basotho – 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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