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08 October 2020 | Story Leonie Bolleurs | Photo Supplied
Vicky Simpson believes our current reality is temporary and that we are more than capable to adjust, regardless of our understanding of what ‘normal’ is.

Vicky Simpson is Development Officer in the Office for Institutional Advancement at the university, where one of her main focus areas is to secure funding for UFS projects and raising funds for student bursaries and the No Student Hungry Programme. 

Simpson, an energetic and proactive person who has a passion for interventions that are humanitarian in nature, says she considers herself lucky to be able to align that which she is passionate about with her career, where she can promote the greater good and create opportunities for others.

“I love working with people and I draw energy from interpersonal interactions. I am an extrovert.”

But the strict lockdown regulations implemented by government in March due to the COVID-19 pandemic, which limited personal interaction – dampened Simpson’s enthusiasm for life.

“The side effect was constant snacking – given that the fridge was next to my temporary office. My energy took a dip and I gained weight.”

Keeping positive

“My partner being a frontline medical worker added additional challenges, given that we had to implement strict routines to keep COVID-19 out of our home. We were both rather drained and had to find ways to keep each other positive.”

Practical as she is, Simpson determined that she craved interaction and fresh air.

“I decided to do video calls with friends and family. This made up for the lack of social contact.”

For fresh air, Simpson started a light exercise routine once South Africans were allowed to go for walks, and gradually increased it. “Exercise and healthy nutritional choices lifted my mood. Basically, I used my time wisely and decided to change my routine for the better,” Simpson adds.

She says the key is to set small goals and to take things slowly. “One small victory at a time.” 

Healthy choices

The pandemic challenged Simpson to embrace a more active lifestyle. “The situation forced me to do introspection, self-care, and nurturing,” she says.

Her advice to others is to make the tough choices. “It is easy to get caught up in a routine where you can’t find the time to go for a walk. Evaluate your routine. Start slowly. And do not forget to drink lots of water, take your vitamins, and eat healthier,” she adds.

Simpson explains that she started off by walking only 30 minutes every second day. But once the serotonin bug bit her, she was hooked. Now she goes for a 5 km run at least once a week. “I simply want to feel healthier again,” she says.

She believes our current reality is temporary and she is looking forward to life after lockdown. 

And what is she looking forward to most? Seeing other people smile. “Yes, I randomly smile at strangers. They always smile back. There is not enough love in this world and small things go a long way,” she says.


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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