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09 October 2020 Photo Supplied
Kgalalelo Motlhabane
A Master of Commerce degree with specialisation in Industrial Psychology will be conferred on Kgalalelo Motlhabane, a graduate and funding officer at the Postgraduate School at UFS on Friday 9 October 2020 in a virtual graduation.

One of the success stories of this year’s virtual graduation is Kgalalelo Motlhabane, a graduate and funding officer at the Postgraduate School, University of the Free State (UFS), who was presented with an award from the National Research Foundation as the best designated authority for 2019.

Motlhabane, who lost her mother when she was in high school, didn’t just have to overcome poverty on her way to her first qualification, but also the fear of ending up on the street. On Friday 9 October she received a Master of Commerce degree with specialisation in Industrial Psychology.

A lot of challenges

“I had a lot of challenges during my first-year undergraduate studies. I could not afford textbooks and stationery. I spent most of my time in the library studying. More often I would be without food and proper clothes to wear.

“I would get warnings from my landlord when the rent was late. Sometimes I would find my room locked and my personal stuff removed. Not being able to pay outstanding fees restricted me from receiving my final results at the end of semesters and exacerbated the situation,” says Motlhabane.

Regardless of all these challenges, she was determined to not give up and return home to the impoverished community of Itireleng village near Pampierstad in the Northern Cape.

Overcoming the challenges

It was actually the distress, poverty and the difficult situation at home, together with her daily struggles that kept her focused. Through hard work, she managed to receive funding from NSFAS for her second and third years and despite the hardships, she obtained her BSocSci degree with distinction at the end of 2012.

“I was then selected to enroll for an Honours degree in Industrial Psychology in 2013. Without any funding prospects for my studies, I wrote to the former university rector Prof Jonathan Jansen, seeking financial assistance.

“Prof Jansen was very impressed with my exceptional academic performance and offered to pay my fees. He also offered me a position to work as a student assistant. I worked for three hours every day before going to the library to do my assignments and prepare for classes, presentations, tests and exams. I completed my Honours degree in 2013.”

In 2014, Motlhabane was employed as an intern at the UFS Human Resources Department and also enrolled for a postgraduate diploma in gender studies, which she obtained at the end of that year. The following year she joined the postgraduate school and started with her Master’s degree in late 2016.

Obtaining a Master’s degree

This was no easy task as she was employed full time which left her with little time to work thoroughly on her thesis, her limited knowledge about research, work pressures and demands, rejections, lack of support, discouragements, accidents and the inability to cope also played a role.  

“I would like to thank God for the strength he gave me to cope throughout my journey, my family for their prayers and continued support, as well as Prof Jonathan Jansen, Prof Petrus Nel and Prof Ebben van Zyl for their kind support and contribution towards my studies. Indeed, the future belongs to those who believe in the beauty of their dreams,” says Motlhabane.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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