Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
13 October 2020 | Story Ruan Bruwer | Photo BackpagePix
Khanyisa Chawane, a Protea player, should be one of the stars for the Free State Crinums in the Telkom Netball League. She was the Player of the League in 2018.

Having to play 11 matches in so many days before the knockout stage will be a daunting task, but their fitness levels are up to standard, says the coach of the Free State netball team. Burta de Kock of KovsieSport will again guide the Free State Crinums in the Telkom Netball League, which will be taking place between 14 and 27 October in Bloemfontein.

All but one of the 12 members of the team are studying at the University of the Free State (UFS).

“Planning will be of the utmost importance to manage the load on the players. We also have four players (Rolene Streutker, Chanel Vrey, Boitumelo Mahloko, and Refiloe Nketsa) who will participate in the South African U21 team that will play five invitational matches during the competition,” said De Kock.

In previous years, the competition took place over four to six weeks, but now it had to be fitted into two weeks due to COVID-19.

“So, it will be a tall order to play so many matches, but an exciting challenge. I believe the hard work the players had put in during the lockdown period will bear fruit. They were exceptional and very determined to stay in shape.”

The Crinums won the first three years of the competition, but couldn’t reach the final in the following three years. Apart from the 11 Kovsies in the Crinums team, there are 9 current or former UFS students in other teams participating in the league. 

They are Zandré Smit, Bianca Pienaar, Dané Klopper, Arné Fourie, Bethenie du Raan (all Northern Cape Diamonds), Maryke Coetzee, Danelle van der Heever (both Mpumalanga Sunbirds), Rieze Straeuli (Western Cape Tornados), and Alicia Puren (KZN Kingdom Stars).

The Crinums team: Boitumelo Mahloko, Ané Retief, Jana Scholtz, Khanyisa Chawane, Lefébre Rademan (captain), Sikholiwe Mdletshe, Claudia van den Berg, Bianca de Wee, Rolene Streutker, Chanel Vrey, Lerato Chabwe, and Refiloe Nketsa.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept