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16 October 2020 | Story Leonie Bolleurs | Photo Supplied
Qinisani Qwabe, one of the Mail & Guardian Top 200 Young South Africans, considers it important to always reach out and contribute to someone's life, no matter how small it may be.

Looking back at 2020, most people will not have fond memories. But for Qinisani Qwabe, a second-year PhD student in the Centre for Sustainable Agriculture, Rural Development and Extension, 2020 turned out to be a good year.

On 10 September, he heard that he was selected as one of the Mail & Guardian Top 200 Young South Africans in the education category. As if being elected as one of the prestigious group of young people is not enough, Qwabe added another feather in his cap when he was chosen as one of 21 young scientists by the Academy of Science of South Africa (ASSAf), in collaboration with the Department of Science and Innovation (DSI). 

When offered the chance to represent South Africa at a BRICS Conference in Russia, he seized the opportunity with both hands. At this virtual event, he presented a paper on a topic he cares about a lot – ecology. His paper, using a South African case study, was titled: The role of agrobiodiversity on environmental management and its impact on human ecology.

Sustainable resources

From an early age, growing up in a very isolated community called iSihuzu on the outskirts of Richards Bay, Qwabe worked hard. He not only reaped the rewards by seeing all his tuition fees paid, but he was also offered opportunities to make a difference in society. 

“I want to see a society that leads a sustainable life and values its natural resources. This is what wakes me up every morning. That is what I am working towards,” he says.

Qwabe has a registered organisation that, among others, seeks to achieve agricultural biodiversity, respect and value for local knowledge, sustainable development, as well as youth and community engagement.  

The organisation has two legs – one dealing with agricultural production and the other focusing on social entrepreneurship. “As part of this social entrepreneurship initiative, we are working with schools in the north of KwaZulu-Natal, where we do outreach programmes (e.g. donating school uniforms), and run projects driven towards sustainability,” says Qwabe.

But he believes that it is his voice on indigenous foods, together with his passion for research – complemented by community development initiatives – that contributed to his selection as one of Mail & Guardian’s top 200 Young South Africans. 

A greater vision

He is happy to be in the academia and believes that it will propel him towards his greater vision. 

“My vision for my future is to be well-known for my contributions on matters of environmental sustainability, and equally so, for community development. Parallel to my philanthropic undertakings, I envision being a leader in one of the leading organisations on environmental sustainability, such as the World Health Organisation's Food and Agricultural Organisation (FAO),” says Qwabe. 

Here he would like to focus his energies on food security, nutrition, and food safety; sustainable management and use of natural resources and forestry; and institutional capacity building for the sustained management of natural resources and increased agriculture production.

The next generation

Qwabe believes he is making an impact and building a solid foundation for the upcoming generations to build upon.  He urges the youth of South Africa to strive to make a difference. “No matter how small it might seem,” he says.

“To borrow from the American songwriter, Michael Jackson – WE are the world. And that 'WEness' denotes that each one of us has a role to play.

 

 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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