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23 October 2020 | Story Andre Damons | Photo Supplied
Dr Potgieter and her team from Beanies4Babies are with women from Westerbloem retirement village, who knit the beanies and socks.

A passion for neonates, especially premature babies, led to an alumna from the University of the Free State (UFS) to co-found Beanies4Babies, an NPO  which provides knitted beanies and socks to all babies admitted to the newborn intensive care unit (NICU) in public hospitals.
Dr Johané Potgieter, a first-year medical intern and co-founder of Beanies4babies, says neonates, especially premature babies, are unable to generate their own heat, and thus are dependent of additional measures to warm them. They have a larger head-to-body surface area which increases their risk for heat loss if the head is not covered. 
According to Dr Potgieter these little miracles have to use all their energy to grow stronger and fight infection instead of generating heat to prevent them from getting too cold. During her studies she was fortunate to learn vital lessons from passionate and vibrant doctors and sisters. One of them, Sr Vanessa Booysen, lit the fire in her heart for neonates, more specifically premature babies, she says.
Need to prevention hypothermia in premature babies and neonates
The dream started in 2018, when she was a 4th-year medical student, doing her first call in the NICU at Pelonomi Tertiary Hospital. “I noticed the need for additional measures to prevent hypothermia in neonates and was eager to actively combat it. I had an amazing idea for a new project, which sadly had little support. I shared my thoughts with my friend, now co-founder, Clarette Cronje.”
“It was challenging, everyone thought this was going to be a once-off donation. However, I knew my dream was too big for limitations like this. After numerous attempts and failures, a door finally opened to liaise with the Mother and Child Academic Hospital (MACAH) Foundation. As they say: ‘Fall seven times, stand up eight’,” says Dr Potgieter. 
The NPO currently provides about 300 packages of knitted beanies and socks a month to all neonates admitted to the NICU in the public hospitals in Bloemfontein and Port Elizabeth. 
The aim is to expand the project nationwide, and according to Dr Potgieter, they are also are launching it in January at Charlotte Maxeke Johannesburg Academic Hospital, where she now works. 
A need exists 
Dr Potgieter says they had always trusted and hoped for something that would change lives but had never imagined it would be on such a scale.  
“There is a need for beanies and socks for these premature babies. We come face to face with this daily and have only scratched the surface. Global statistics for premature births are one in every 10 births. National statistics are one in every seven births. 
“Premature and newborn babies cannot generate their own heat through shivering or adding additional layers of clothing to their skin. They are exposed to the surrounding air and objects, increasing their risk for heat loss. They lose a great deal of heat from their heads, making it of critical importance to cover their heads. A large number of our mothers go into premature labour, with an earlier due date than planned, arriving in an ambulance without a newborn’s clothes. So it is clear that a bigger hand is driving this project,” says Dr Potgieter. 
Also involve the elderly
Beanies4Babies not only focuses on supporting neonates, but also involves the elderly in the community who knit the products for project. “The angels at the old age homes eagerly knit away. But they need wool. Donations for wool and packaging are needed to service hospitals in three provinces (Free State, Eastern Cape and Gauteng).”
“Volunteers and financial support are also needed as operations have been scaled up to ensure efficiency.”
Says Dr Potgieter: “We are privileged to have a dynamic team of doctors, students, sisters and allied health professionals who support our project.”
Beanies4Babies now functions as one of the First 1000 days projects of the MACAH Foundation that aims to optimise the future for the young generation. 
“I am blessed to have the opportunity to do what I love and that is to make a difference.” 

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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