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28 October 2020 | Story Nitha Ramnath


Lunchtime learning webinar series on Interdisciplinarity in Action

Mastering a musical instrument, such as the piano, requires the simultaneous integration of a multimodal, sensory system and motor information with multimodal, sensory feedback mechanisms that continuously monitor the performance. Performing intricate movements requires complex, sensory-motor programming of finger and hand movements, which can result in a reorganisation of the brain regarding functional and structural changes of existing and the establishment of new connections. Neuronal networks involved in music processing are adaptable and fast-changing. When motor skills are simplified to the most important action, it consists of nerve impulses sent to the muscles.

In this webinar, Dr Frelét de Villiers discusses the interdisciplinarity between the two fields of music and neuroscience. Promising preliminary data has been reported for applications of transcranial direct stimulation (tDCS) of the motor cortex, ranging from stroke rehabilitation to cognitive enhancement. These findings raise the alternative possibility that the fine motor control of pianists may be improved by stimulating the contralateral motor cortex. 

In our interdisciplinary study, we want to use the Halo Sport neurostimulation system (a physical training aid). This is a tDCS device, designed to optimise the efficiency of training sessions and accelerate gains in any physical skill, especially when the neurostimulation is complemented by focused repetitive training. The main questions of the study are the following: do pianists experience a noticeable difference in mastering repertoire with and without the HALO Sport device, and can functional and structural changes in the brain be observed after using the Halo Sport consistently over six months? Data collection will consist of EEG tests, fMRI scans, interviews, and analysis of performances by an expert panel. The value of the research is the possibility that practising with the HALO may improve the performance of the students and that changes in the brain may be observed. Interdisciplinary engagement is essential to conduct this research. If it is possible to establish that there are functional and structural changes in the brain and improvement in the performance of the pianists, the research can be extended to other disciplines with hopefully the same positive results.

This webinar is part of a series of three webinars on Interdisciplinarity that will be presented from November to December 2020 via Microsoft Teams for a duration of 45 minutes each. The webinar topics in the series will explore the intersection between Neuroscience and Music, between Science and Entrepreneurship, and between Science and Visual Arts.  

Date: Thursday 5 November 2020
Topic: The intersection between neuroscience and music 
Time: 13:00-13:45
RSVP: Alicia Pienaar, pienaaran1@ufs.ac.za by 4 November 2020 at 12:00
Platform: Microsoft Teams

Introduction and welcome
Prof Corli Witthuhn – Vice-Rector: Research at the University of the Free State 

Presenter
Dr Frelét de Villiers

Dr de Villiers is a Senior Lecturer at the Odeion School of Music. She is head of the Methodology modules, short learning programmes, lectures in piano, music pedagogy, arts management, and is a supervisor for postgraduate students. She is a member of the Faculty of the Humanities Research Committee, Interdisciplinary Centre for Digital Futures, Scientific Committee (Arts), and the Ethics Committee (the Humanities). Her field of expertise is piano technique, with particular emphasis on the influence of the brain and the whole-brain approach to music. Her passion is the use of technology in the music teaching situation – she developed a note-learning app, PianoBoost (available on Google Play).

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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