Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
28 October 2020 | Story Nitha Ramnath


Lunchtime learning webinar series on Interdisciplinarity in Action

Mastering a musical instrument, such as the piano, requires the simultaneous integration of a multimodal, sensory system and motor information with multimodal, sensory feedback mechanisms that continuously monitor the performance. Performing intricate movements requires complex, sensory-motor programming of finger and hand movements, which can result in a reorganisation of the brain regarding functional and structural changes of existing and the establishment of new connections. Neuronal networks involved in music processing are adaptable and fast-changing. When motor skills are simplified to the most important action, it consists of nerve impulses sent to the muscles.

In this webinar, Dr Frelét de Villiers discusses the interdisciplinarity between the two fields of music and neuroscience. Promising preliminary data has been reported for applications of transcranial direct stimulation (tDCS) of the motor cortex, ranging from stroke rehabilitation to cognitive enhancement. These findings raise the alternative possibility that the fine motor control of pianists may be improved by stimulating the contralateral motor cortex. 

In our interdisciplinary study, we want to use the Halo Sport neurostimulation system (a physical training aid). This is a tDCS device, designed to optimise the efficiency of training sessions and accelerate gains in any physical skill, especially when the neurostimulation is complemented by focused repetitive training. The main questions of the study are the following: do pianists experience a noticeable difference in mastering repertoire with and without the HALO Sport device, and can functional and structural changes in the brain be observed after using the Halo Sport consistently over six months? Data collection will consist of EEG tests, fMRI scans, interviews, and analysis of performances by an expert panel. The value of the research is the possibility that practising with the HALO may improve the performance of the students and that changes in the brain may be observed. Interdisciplinary engagement is essential to conduct this research. If it is possible to establish that there are functional and structural changes in the brain and improvement in the performance of the pianists, the research can be extended to other disciplines with hopefully the same positive results.

This webinar is part of a series of three webinars on Interdisciplinarity that will be presented from November to December 2020 via Microsoft Teams for a duration of 45 minutes each. The webinar topics in the series will explore the intersection between Neuroscience and Music, between Science and Entrepreneurship, and between Science and Visual Arts.  

Date: Thursday 5 November 2020
Topic: The intersection between neuroscience and music 
Time: 13:00-13:45
RSVP: Alicia Pienaar, pienaaran1@ufs.ac.za by 4 November 2020 at 12:00
Platform: Microsoft Teams

Introduction and welcome
Prof Corli Witthuhn – Vice-Rector: Research at the University of the Free State 

Presenter
Dr Frelét de Villiers

Dr de Villiers is a Senior Lecturer at the Odeion School of Music. She is head of the Methodology modules, short learning programmes, lectures in piano, music pedagogy, arts management, and is a supervisor for postgraduate students. She is a member of the Faculty of the Humanities Research Committee, Interdisciplinary Centre for Digital Futures, Scientific Committee (Arts), and the Ethics Committee (the Humanities). Her field of expertise is piano technique, with particular emphasis on the influence of the brain and the whole-brain approach to music. Her passion is the use of technology in the music teaching situation – she developed a note-learning app, PianoBoost (available on Google Play).

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept