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10 September 2020 | Story Barend Nagel | Photo Barend Nagel

There is a notable quote by one of the most prolific and influential composers ever, that says: 

“The music is not in the notes,
but in the silence in between.”
- Wolfgang Amadeus Mozart

Mozart’s proclamation is relevant, now more than ever. In many cases, we may not realise that those who are more silent than others are most likely faced with adversity in terms of their mental health.

To counteract this silence, UFS Clinical Psychologist, Angela Vorster from the School of Clinical Medicine, devised the UFS Medical Students ‘Unplugged’ initiative as part of a larger campaign. Vorster says the campaign creates an opportunity to encourage students to reconnect with their soulful side.

“Each year we choose a mental-health issue and focus our theme on raising awareness – e.g. suicide awareness.” This year’s theme is ‘In my blood’ depression and anxiety awareness. Sadly, the 2020 ‘Unplugged’ event had to be cancelled due to the unfortunate (and mentally taxing) circumstances we are currently facing around the globe. Nonetheless, Vorster’s evident compassion and benevolence towards individuals’ mental health did not allow the pandemic to discourage her from finding innovative ways of keeping harmony.

“Once we all returned to a 'new normal', I invited our students to submit recordings of their music. This then became a channel of its own on YouTube – and we could not be prouder of our musically talented students.” According to Vorster, research and literature have established that music has a significant impact on relieving emotional distress and improving our moods. “It became evident during therapy sessions how important music is in helping our students express their emotions, relax, and also engage their creativity,” says Vorster.

With Mental Health Month inching it’s way closer, and World Suicide Prevention Day on 10 September, we should all embrace the ‘magic’ of music and the positive effects it has on our psychological and mental well-being. So, turn up the volume and defeat the silence in your life with your favourite music. Play an instrument, turn up the volume on your iPod, sing in the shower, or watch the UFS Students ‘Unplugged’ videos on YouTube; allow music to heal your ‘silences in between’.

 


News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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