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10 September 2020 | Story Eugene Seegers | Photo Sonia du Toit (Kaleidoscope Studio)
Dr Marinkie Madiope in official UFS gown
Dr Maria Madiope

Everywhere you look, our colleagues at the UFS are stepping up and stepping into the new digital space. With the move to virtual events, staff members at the university are able to participate in discussions and webinars across the continent at various other institutions of higher learning. 

One such virtual event recently took place for Women’s Month. The Tshwane University of Technology hosted the Annual Adelaide Tambo Memorial Lecture on 27 August. The theme was Is the face of the boardroom in global organisations changing women representation in influential positions?

Dr Phumzile Mlambo-Ngcuka, United Nations Under-Secretary General and Executive Director of UN Women, focused in her presentation on themes regarding girls’ education and women’s health, both of which have been threatened by the COVID-19 pandemic.

As the respondent, Dr Maria Madiope, Principal of the UFS South Campus, dealt with the patriarchal domination and violence that modern women and girls endure, as well as the way “their sexuality and aptitude is disrespected and how they are subjugated and side-lined in the political, corporate, social, and cultural arena.” She said that it is incumbent on the modern generation of women to reignite the flame that fuelled the struggle for feminine recognition and equality. “We are beholden not only to the legacy of those that came before us, but also to the eager eyes that look up to us,” she concluded. 

Dr Madiope also announced her support for Dr Mlambo-Ngcuka’s Generation Equality campaign against gender-based violence, and she echoed the sentiments of the rallying hashtag #JustChair, which breaks down discrimination based on the use of gendered terms such as ‘chairman’ for the leader of a meeting or corporation.

Dr Adelaide Tambo’s life was characterised by a love of knowledge, as she believed that people need as much power to be able to handle challenges facing the country, the continent, and the planet. She strove for the emancipation of women in general, focusing on the importance of education and how it can improve a woman’s life, and encouraged a strong culture of learning.

The event was livestreamed on Facebook and Zoom; go to https://www.facebook.com/805899996152814/videos/1036964343420927 to watch the full presentation.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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