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30 September 2020 | Story Nitha Ramnath | Photo Supplied
SWSA represented by Mariné du Toit (left) and Lyshea Mapaike(right) at the handover of the funds raised

Sunflower Children’s Hospice, situated on the ground floor of the National District Hospital, is a non-profit organisation that provides care and compassion for all children with life-threatening and life-limiting conditions. As far as possible, the hospice aims to keep children within their families and communities, with relevant supervision and support.  However, the hospice is also a permanent residence to many children.

At Sunflower Children’s Hospice, children and their families are provided with:
• palliative care, including pain and symptom management;
• quality of life;
• relief of suffering;
• support for child and family/guardians;
• developmental stimulation;
• support during the bereavement period;
• dignity in death;
• community participation; and
• relevant training.

Due to limited funds, the hospice experiences many financial challenges, which motivated the Social Work Student Association (SWSA) to become involved. Their involvement led to the establishment of the ‘#Adoptaflower’ project by raising funds for the organisation and getting more Social Work students to spend time with the children, as they do not have enough caregivers at the house to give them the special personal attention that they need.  This project was spearheaded by Mariné du Toit, Portfolio Head: Community Upliftment of the SWSA. 

The fundraising initiative collected R1 300 from selling raffle tickets to the university community.  Due to COVID-19 and the lockdown period, it became impossible to proceed with the intention of the Social Work students to spend more time with the children.  

Besides Social Work students not being able to proceed with their intention of interacting more closely with the children concerned, the lockdown unfortunately also affected it negatively in other areas.  The hospice needs assistance with clothes, toiletries, and groceries. Sunflower House therefore needs funds and sponsors to continue providing services to so many children in need of care and support. For more information regarding public involvement, 051 448 3813 is the number to call. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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