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06 April 2021 | Story Thabo Kessah | Photo Thabo Kessah
Ntebohiseng Sekhele is the Associate Guest Editor of the recent Special Issue of the African Journal of Range & Forage Science.

The Director of the Afromontane Research Unit (ARU), Dr Ralph Clark, and researcher, Ntebohiseng Sekhele, recently became part of a guest editorial team for the African Journal of Range & Forage Science. The Special Issue titled, ‘Montane rangelands in a changing world’, was published on 3 March 2021.

“I feel privileged to have been part of the team that assembled this special issue. The experience was daunting at first, as I had never been part of an editorial team before. However, with the support of the guest editors and the journal’s administrator, I was able to overcome the imposter-syndrome feeling and allowed myself to learn and enjoy the ride. My ‘aha’ moments were the critical comments from the reviewers on each paper. It was amazing to witness how this feedback would enhance the quality of an article,” said Ntebohiseng Sekhele, Geography lecturer on the Qwaqwa Campus.

Journal focus

This issue focused on the applied management of montane rangelands for production in Southern Africa and the broader world. Submissions could include original research, reviews, and meta-analyses. This has culminated in contributions that centred on the impact of policy on pastoral practices by montane communities, fire management regimes, cumulative effects of poor governance on rangeland degradation, and sustainable grazing systems – including in ecological infrastructure such as montane wetlands and communal rangeland. 

“The process took almost a year, as the first call for abstracts was made in December 2019 and final revisions of accepted papers were concluded in November 2020. There were 32 submissions with only 12 articles and one book review of Prof Rodney Moffett’s book, A Scientific Bibliography of the Drakensberg, Maloti and Adjacent Lowlands. Of the 12 contributions, nine focus on the Maloti-Drakensberg, with papers on Lesotho, KwaZulu-Natal, and the Free State,” she revealed. 

Submitted papers

“All papers advocate for the sustainable management of sensitive montane systems, which ties well with my own research that makes a contribution to the limited scholarship of natural resource-related conflicts between montane communities and their adjacent protected areas, as well as climate change impacts on natural resources,” said Sekhele, a PhD candidate through the ARU’s US-SA University Staff Development Programme (USDP). The special issue allowed for a closer link between the US and SA USDP through the involvement of Dr Kryan Kunkel – Ntebohiseng’s US co-supervisor – as one of the guest editors. 

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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