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14 April 2021 | Story André Damons | Photo Supplied
Keabetswe Modise is graduating cum laude with a Bachelor of Administration Honours degree during the UFS virtual graduation on 19 April.

After repeating Grade 11 three times, a student in the Faculty of Economic and Management Sciences at the University of the Free State (UFS) is graduating cum laude with a Bachelor of Administration Honours degree in April.

Keabetswe Modise, who is graduating on 19 April during the UFS virtual graduation, says she used her earlier failures as motivation to work even harder. 

“I am extremely proud of myself. I chose to win instead of crying over spilled milk. As a black, capable, and independent woman, I told myself that if there is a chance for trauma or depression, there is definitely a chance to succeed and enjoy life. This implies that I can achieve anything that I set my mind to. I now hold my family’s name high in both our community and within our external family,” says a proud Modise.

Modise, a part-time lecturer at the Central University of Technology (CUT) in Welkom, has been accepted to study a Master of Public Policy and Development degree in Japan. Her academic year will commence early in 2022 and will take two years to complete.   

Motivation

“This (academic success) came as a surprise. I never thought that one day I would hold a postgraduate qualification, let alone that such a qualification exists. In high school, I repeated Grade 11 three times. At that time, I was known as the dumbest kid in school and in the community. 

“I was depressed, but I did not know what was going on with me. Therefore, I just wanted to pass my matric and work to survive. During my matric year, I really became more motivated after career orientation. This is when I knew I wanted to experience university life. I also wanted to use the chance to escape the dumb girl concept and come back with a victory to claim back my name. Today I am the most influential girl in my community.”

Making the most of the lockdown

Modise used the COVID-19 pandemic and the lockdown to her advantage, as it gave her the opportunity to not only study online, but to also start a successful fast-food business. 

“The consequences of the pandemic on universities have been to my advantage. I managed to work at home, with limited financial expenses such as transport and printing of documents. Also, my assessments were online. This also gave me the chance to start a fast-food business while tackling academic activities on time. 

“Most importantly, I did not have money for registration, and when the policy changed for late registration due to COVID-19 regulations, it gave me time to make a plan to finance my studies. Fortunately, by August, I received a bursary from the Postgraduate School at the UFS, because the HOD was impressed with my academic record. As much as the effects of COVID-19 were devastating on the lives of people, I managed to achieve my goal,” says Modise. 

Her inspiration 

According to Modise, her parents – who separated when she was very young – inspire her. Says Modise: “I appreciate everything they have done for me. I just want my father to one day address me as Dr Modise, while he and my mother can look back and be proud of the woman I have become.” 

“In this case, I can say that I get inspired by the vision of being applauded by both my mother and father.  Most importantly, I get inspired by the changing philosophy of government management. I admire the impact of globalisation around the world. Today, any academic institution can operate online.” 

Modise’s message to others is that nothing comes easy or without a cost: “It looks like it is impossible, but actually, this is your life. I can motivate someone as much as I can, but if you are not willing to be motivated, nothing can change for you. Also, no one owes anyone anything. This is your journey, drive it.”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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