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20 April 2021 | Story André Damons | Photo André Damons
Hannes Erasmus, an assistant bioanalyst in the Division of Immunochemistry at FARMOVS, a wholly owned clinical research company of the University of the Free State (UFS), will be graduating on Friday with a Master of Science degree majoring in Human Molecular Genetics.

While working on his study for his MSc Human Genetics degree, a staff member of FARMOVS – who was a Gamete intrafallopian tube (GIFT) baby – not only got to meet the doctor who was responsible for his being, but the doctor also formed part of his supervisor team.

Hannes Erasmus, an assistant bioanalyst in the Division of Immunochemistry at FARMOVS, a wholly owned clinical research company of the University of the Free State (UFS), will be graduating on Thursday (22 April 2021) with a Master of Science degree majoring in Human Molecular Genetics. His dissertation is titled Genetic and Molecular Analysis of Male infertility in a private practice in South Africa. His supervisor team consisted of Mrs Sue-Rica Schneiders (supervisor), Dr Gerda Marx, Dr Olga de Smidt, and Prof PH (Paul) Wessels (co-supervisors).

“I feel very proud and fortunate to have the opportunity to complete this achievement. It was not easy, but it gave me more time during lockdown to write up my thesis. One of my biggest challenges was time itself. Late nights in the lab and writing up at night,” says Erasmus about studying and working during the year of COVID-19.

GIFT baby

According to Erasmus, he decided on this topic because he had an interest in infertility from an early age, since he was also a GIFT baby. 

“My parents struggled for a while to conceive after my older sister was born.  They decided on this assisted reproductive technique, and I was conceived. I then had the privilege to meet the doctor who was responsible for my being, Prof Wessels.  He then also formed part of my supervisor team and allowed me to sample my case group at his private fertility clinic.”

His wife, Bernadine, inspires him to be a better version of himself each day.  He strives to contribute to his workspace, his friends, family, and community to grow and better the future of South Africa and our children.

Dean’s Medal 
A colleague of Erasmus – Vicky Simpson, Marketing Manager of FARMOVS, is the recipient of the Dean’s Medal for achieving the best results in respect of a Bachelor Honours degree in the Faculty of Economic and Management Sciences at the UFS. 

Simpson, who graduated with a Bachelor of Commerce Honours with specialisation in Marketing during the virtual graduation on Monday, says she is shocked and at first did not notice that she was the recipient of this award. She obtained her degree with distinction.

“I will always be grateful! Not everyone gets the opportunity to study at a university. Yes, I had to work twice as hard to achieve my goals, but I think I craved success enough to overcome all the challenges.”

                            Vicky Simpson, Marketing Manager of FARMOVS,Picture: André Damons


Grabbed the opportunity with both hands

“I never had the opportunity to study before the age of 30. My family had very limited financial resources.  As a result, my main focus was day-to-day survival. So, I had to find creative ways to make this dream happen. When the doors of opportunity opened here at the UFS, I grabbed it with both hands and made the best of numerous challenging situations. It meant that I had to study and perform well at work, because both aspects deserved my full attention. In the end, I don’t regret the sacrifices I made. I also hope that I made those who believed in my potential very proud,” says Simpson.

“I will always remain grateful to Prof Jonathan Jansen, former Rector and Vice-Chancellor of the UFS, and his wife Grace. They gave me a valuable opportunity back in 2014, which transformed my life. My colleague Pat Lamusse also played a significant role in my development, because she believed in me when it mattered the most.” 

According to Simpson, it was difficult to stay motivated and focused (during COVID-19) while the world was in a state of turmoil and uncertainty.  It required more energy than it would have under normal circumstances. 

“Luckily, my partner Cornél, my friends, colleagues, and family were there to offer me support. I felt like quitting a few times, but grit and vision pushed me forward towards my goal. My amazing study leader, Prof Jacques Nel, was just so inspiring and helpful. We made a stellar team, and my dissertation remains the best document that I have ever submitted. The weekends and late nights spent on writing that document was worth it!”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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