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09 April 2021 | Story Dr Nitha Ramnath | Photo Supplied
Tiisetso Mokoena tops the UFS Management Development Programme class of 2020

A tough 2020 did not dampen the spirit of Tiisetso Mokoena. Determined and steadfast, she obtained the highest average (92%) to become the top student in the Management Development Programme (MDP) offered by the University of the Free State (UFS) Business School. Mokoena enrolled for the MDP after receiving a bursary from the Services SETA. This is a remarkable achievement, as not only did Mokoena have fierce competition from an exceptionally large group – COVID-19 presented its own challenges that Mokoena had to face. Mokoena transitioned seamlessly from traditional face-to-face to online learning and excelled at it.

“Ms Mokoena was a very enthusiastic and committed student. She worked extremely hard and was not deterred by the transition from face-to-face to online lectures. Her hard work paid off, with impressive results. We are very proud of her,” says Programme Coordinator, Jo’Anni Deacon.

Mokoena also adds: “It has been a great honour to be part of the Higher Certificate Management Development Programme (MDP), and I thank my employer, Services SETA, and the UFS Business School for making it all possible.”
“My overall experience of the programme was impressive. I came into it with an expectation to better myself in my career; I believe that I will achieve this, as I was presented with tools and techniques that will help me grow professionally. As I went through the programme, I developed a sense of ambition and my strategic thinking progressed. I learned a lot about the basics of an everyday business world as we went through different modules, and there were a lot of ‘aha’ moments,” Mokoena adds.

“The UFS Business School is phenomenal, the academic support we as students received throughout the programme was amazing – we were treated with such dignity. The staff took time and effort to assist us with the utmost care and professionalism,” says Mokoena about her experience in the UFS Business School. 

About the UFS Business School and the Higher Certificate in Management Development

The Business School within the Faculty of Economic and Management Sciences has established itself as a leader in South Africa with the provision of the Higher Certificate in Management Development. A dynamic supplement to this spectrum of management programmes on offer is an excellent Higher Certificate in Management Development (MDP). The MDP emphasises leadership development, broadens insight through exposure to the most important management disciplines, and integrates it into a total management approach. This tailor-made qualification has been designed to assist institutions, managers, and managers-to-be in both the private and public sectors.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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