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30 April 2021 | Story Dr Cindé Greyling | Photo Supplied
René and Richann as Reën.

In the same week, a lecturer at the University of the Free State graduated with a master’s degree in Political Science and topped the charts with her first single as part of the duo, Reën. Within the first week of its release, Vrystaat Vlaktes was the number one hit on iTunes, got more than 300 000 views, and the duo’s Instagram boasts more than 10 000 followers. Not bad for the shy – as she describes herself – René de Klerk. 

An interesting start 

After living in Canada for about four years, René’s family moved back to Bloemfontein where she completed the last three years of high school. She decided to return to Canada after matric for a gap year, which “turned out to be nothing like that at all!” she says. Life was much harder on her own without the protection and support of her family. “Eventually I got a job, and part of my duties were to clean the restrooms – seriously. That is where I started.” 

After applying for dozens of scholarships, René eventually got a bursary to study abroad. “I’ve always wanted to help people in some way – I really want everyone to be OK, to at least have their basic needs met.” She enrolled for a degree in International Studies, which she later completed at the UFS as a BA majoring in Political Science and Communication. Her academic potential did not go unnoticed, and she pursued further studies in Political Sciences while working and lecturing in the department.

A twist in the tale 

René met her partner, Richann Brüssow, during the reality show, Boer Soek ‘n Vrou. “Since I am shy by nature, being so exposed was unnerving, but then again, I got so much out of it.” The two hit it off as a couple, and their shared love for music soon turned into much more than either of them foresaw. “We were honestly just having fun,” René recalls, “and then a production company contacted us!” 

Initially, they thought of becoming wedding singers as a hobby, but Select Music found out about their endeavour and offered them an artist development deal. “I’m astonished,” René says, “my music background included school and university choirs. I never even considered becoming a performing artist. But then I met Richann …”

More to come

This is just the beginning of the road for René and for Reën. René will continue to leave a positive footprint wherever she goes, and Reën is soon to release their second single. “I will always be working in the field of Political Sciences and spend time in the music scene as a bonus,” she concludes. 


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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