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08 April 2021 | Story Thabo Kessah | Photo UFS Photo Archive
Dr KPD Maphalla with former UFS Chancellor, Dr Franklin Sonn, during the graduations in April 2007.

The University of the Free State is sad to learn of the passing of alumnus and award-winning Sesotho literary giant, Dr KPD Maphalla. 

The literary works of Dr Khotso Pieter David Maphalla, like many other African writers and artists, were influenced and characterised by his own era of powerful forms of oppression and exclusion from dominant literary discourses. In his own right and through his writings of poetry, novels, short stories, and kodiamalla (dirge), he articulated a deliberate political and social protest and pushed for a place for African languages in literature at the height of apartheid.  

Ground-breaking novel 

 “He entered the professional scene with his ground-breaking novel, Kabelwamanong, in 1982 at the age of 27.  His career actually started in 1971 while he was still at school. Since his first novel, he has produced at least two books annually, covering the genres of poetry, novels, dramas, and short stories. As a dramatist, Dr Maphalla has written a number of excellent and educative radio dramas for the then Radio Sesotho (now Lesedi FM),” said his long-time friend and Head: African Languages at the University of the Free State, Dr Nyefolo Malete. 

Honorary degree 

“It was for this writing prowess that he received recognition from the UFS when he was awarded an Honorary Doctorate in Literature by the Department of African Languages during a momentous ceremony on the Qwaqwa Campus in 2007,” added Dr Malete. 

Dr Malete also revealed that, despite losing the use of his right hand after suffering a stroke following a car accident in the late 1990s, Dr Maphalla continued writing using his left hand. “He was adamant that, what he referred to as his ‘supposed disability’, would not deter his passion for writing.”  

Scholarly studies 

Dr Maphalla’s work has also produced numerous scholarly studies by the likes of Profs Moleleki Moleleki (protest poetry), Thapelo Selepe (lament and protest poetry), and Dr Seema Seema (process of cross-cultural communication). He was a committed Qwaqwa community member, who was also instrumental in the founding of Qwaqwa Community Radio (2000) and Metjodi Writers (2006), among others. He has written more than 70 books, many of which have been prescribed texts in schools. 

Some of the awards he has won include: 

  1. South African Centre for Digital Language Resource (SADiLar) Sesotho Lexicographic Unit (Sesiu sa Sesotho) Lifetime Award for outstanding literary works and for promoting Sesotho literature (2019). 

  1. The Literature Festival and the University of the Free State Award for enormous contribution to Sesotho literature by a South African writer (2019). 

  1. Lifetime Achiever Award in Literature awarded by the Department of Arts and Culture (2005). 

  1. M-Net Book Prize for Sesotho poetry (2005).  The first and thus far the only Sesotho author to have received this honour. 

  1. M-Net Book Prize for best novel (1996). 

  1. De Jager-HAUM Literary Award for his volume of short stories, Mohlomong Hosane (1993). 

  1. Thomas Mofolo Trophy for Best Novel, Best Poetry, and the Overall Award (1992). 

  1. Thomas Mofolo Trophy for Best Poetry (1991). 

  1. Dr JJ Moiloa Floating Trophy for Best Sesotho Poetry Book of the Year, Kgapa tsa ka (1985). 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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