Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
17 August 2021 | Story Dikgapane Makhetha | Photo Supplied
Bishop Billyboy Ramahlele (Director: Community Engagement), Napo Masheane (lead actress), and Troy Myeni (Director)

A short fiction film that was shot in Botshabelo and on the Bloemfontein Campus of the UFS, has once again shown the endless possibilities of engaged scholarship in the creative arts.

For this film project, engaged scholarship meant working with graduates / current students from the UFS on projects with a relevant and impactful theme for the broader community. The project was aimed at giving current or past students the opportunity to gain experience or share experience and to transfer skills in the area of filmmaking. 

The short fiction film, Leshano (The Lie), was directed by Mpendulo ‘Troy’ Myeni, a graduate of the UFS Film Programme, who also won an award at the Pan African Film Festival in the US for another of his short films.  Troy was also one of the three co-producers, along with Anton Fisher (a former employee of the UFS), who wrote the script, and Moeketsi Mphunye, a young filmmaker from Botshabelo.
Another notable UFS graduate who was central to the production, is Mbuyiselo Nqodi. He graduated with a BA in Drama and Theatre Arts and has since gone on to make a huge contribution to the performing arts in the Free State and South Africa. Mbuyiselo was the first assistant director of Leshano (The Lie) and had the unenviable job of keeping everything moving on set.  Other members of the production registered at the UFS, but never completed their studies. 

Bishop Billyboy Ramahlele, Director of Community Engagement at the UFS, said he was proud that the UFS could be part of this filmmaking project by making offices available as locations for the film and through the participation of distinguished graduates in key positions of the production.

“The UFS has much to offer young people as students, but also as graduates who seek to advance in their chosen careers. Through community engagement, these young people, whether students or graduates, can be inspired by working with professionals in various fields and gaining hands-on experience. They can then plough back into the community and the UFS.”

“This is the virtuous cycle of community engagement at a university. Students gain knowledge, then they gain inspiration and experience, and plough back into the UFS and broader community, instilling hope for future generations,” Bishop Ramahlele said. 

He added that the UFS would be mentioned in the credits of the film and in publicity and marketing of the film, profiling its reputation as a centre of creative excellence.

Leshano (The Lie) was filmed in Sesotho, with English subtitles, and deals with the important issue of corruption. The lead role is played by the acclaimed Napo Masheane who grew up in Qwaqwa, supported by well-known Free State actors Maria de Koker, Seipati Mpotoane, Ntsiki Ndzume, Vincent Tsoametsi, Pesa Pheko, and Shayne Nketsi. 

Several young, aspiring filmmakers from across the Free State were recruited for the project. It was their first time on the set of a film production, whether as make-up artists, behind the scenes photographers, unit production managers, wardrobe assistants, or location scouts. 

With a strong line-up of women in the lead roles, the film will be released later in August during Women’s Month. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept