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12 August 2021 | Story Dr Nitha Ramnath

As a public higher-education institution in South Africa with a responsibility to contribute to public discourse, the University of the Free State (UFS) will be presenting the webinar as part of the Free State Literature Festival’s online initiative, VrySpraak-digitaal.

The aim of the webinar series is to discuss issues facing South Africa by engaging experts at the university and in South Africa. Some of the topics for 2021 include, among others, reimagining universities for student success; corruption; local elections, the state of business – particularly in the Free State.

In 2020, the webinar series saw the successful participation of leading experts engaging on COVID-19 and the crisis facing the country socially, economically, and politically. This year, in lieu of the Free State Arts Festival, the UFS will present the webinar virtually over a period of five months.

Fourth webinar presented on 24 August 2021
What South Africa will look like after the recent unrest in KwaZulu-Natal and Gauteng, is yet unknown. As the country is attempting to normalise while tallying the human, political, and economic cost of the riots – what we know for sure is that the events of the past few weeks have dispelled the impression of South Africa as exceptional, with a triumphant future. Moreover, the inconsistent response from government during and after the unrest laid bare the divisions within the ruling party. As South Africans are reeling from the aftermath of the looting, a lacklustre response from leaders with unreliable, conflicting messages has brought little comfort to those most in need.

What happens now? What will it take for South Africans to advance a cohesive vision to provide a sustainable future for the next generation?

Date: Tuesday, 24 August 2021
Topic: Is South Africa falling apart – where to from here?
Time: 12:30-14:00
RSVP: Alicia Pienaar, pienaaran1@ufs.ac.za by 20 August 2021

Facilitator:

Prof Francis Petersen
Rector and Vice-Chancellor, UFS

Panellists:

• Prof Bonang Mohale
UFS Chancellor
Professor of Practice
Johannesburg Business School, and
Chairman Bidvest Group Limited

• Nikiwe Bikitsha

Board Member: Nelson Mandela Foundation
CEO and co-founder: Amargi Media

• Qaanitah Hunter

Political Editor: News24

• Prof Anthony Turton
Affiliated Professor
UFS Centre for Environmental Management

Bios of speakers:

Prof Bonang Mohale

A Professor of Practice at the Johannesburg Business School’s College of Business and Economics, and Chairman of the Bidvest Group Limited, Prof Mohale is a published author and respected business leader who has held chairmanships and directorships at some of South Africa’s top companies. He currently serves on the boards of Swiss Re Africa Limited, Rand Merchant Bank Limited (RMB), the Automobile Association of South Africa, and SBV. Prof Mohale was the former Chief Executive Officer of Business Leadership South Africa (BLSA). In 2001, he received the President’s Award for his servanthood in South African industry, and in 2019 the Free Market Foundation’s Luminary Award. Prior to joining BLSA, Prof Mohale was the Chairman of Shell Downstream South Africa (Pty) Limited, and Vice-President of Shell Upstream.
Ms Nikiwe Bikitsha

Nikiwe Bikitsha is a former journalist who has been at the forefront of major national and international developments in a news and current affairs broadcasting career spanning twenty years. Nikiwe is a Fulbright Hubert H Humphrey Fellow – the Humphrey programme is a mid-career Fulbright exchange fellowship awarded to people who have demonstrated leadership. Nikiwe holds an MA in Journalism and Media Studies from the University of the Witwatersrand, and an MSc degree in African Studies from the University of Oxford. She serves as trustee on the board of the Nelson Mandela Foundation, is a member of the Deloitte Global Advisory Council and an independent non-executive director of Deloitte Africa. Despite leaving journalism, Nikiwe remains a keen observer of society.
Ms Qaanitah Hunter

Qaanitah Hunter is an award-winning political journalist and author. She is the political editor of News24 and author of Balance of Power: Ramaphosa and the future of South Africa. Qaanitah has won a number of awards for her work, including the Nat Nakasa award for brave and courageous journalism in 2019. She is currently a master’s student at the University of the Witwatersrand.  She has reported fearlessly on state capture, the Zuma years, and the political transition thereafter. Her constant probing and investigations have played a pivotal role in holding truth to power. Her writing on South African politics and investigations has featured prominently on many national media platforms, often setting the agenda in the country. Qaanitah is well-versed in issues of governance and her well-rounded and balanced political reporting has contributed to her astute analysis of news and current affairs. She has fought strongly against censorship and intimidation among journalists and has been a strong advocator for the freedom of the press. Qaanitah believes that the prospect of any democracy to persevere is pinned on how free the media is and its ability to hold those in power accountable.
Prof Anthony Turton

Prof Anthony Turton is an Affiliated Professor in the Centre for Environmental Management at the University of the Free State (UFS). He specialises in strategic planning, transboundary water resource management, policy and institutional issues, conflict resolution (mitigation), political risk assessment for large infrastructural projects, and research programme design. He is also the Director of Nanodyn Systems Pty Ltd. Prof Turton’s focus is on resources, more specifically the need to overcome water and energy constraints to our future economic growth and prosperity, both as a country and the entire SADC region. As an environmentally aware person, he believes that we are reaching the limits to our current developmental approaches and will be forced to make changes in the near future, whether we like it or not. By understanding and anticipating this, Prof Turton assists organisations in staying ahead of the game by isolating fundamental drivers at work and by identifying emerging opportunities.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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