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06 August 2021 | Story Dr Cindé Greyling | Photo André Damons
Nombulelo Shange - Making a positive impact with writing

Nombulelo Shange is a lecturer in Sociology in the University of the Free State (UFS) Department of Sociology and one of our top opinion article writers – regularly quoted by the media. She is also currently a PhD candidate in Anthropology, studying a Cape Town community called the ‘mountain doctors’. 

What is the best thing about your job?

I love my students and have missed them so much during this precarious time. 

What is the best and worst decision you have ever made?

Although I loved teaching English in South Korea, I was young and became extremely homesick, so I ended up coming back prematurely – leaving me unemployed for three years. Later, I was accepted by the University of St Andrews in Scotland for my PhD, but in the end, I sadly had to turn that opportunity down because of finances. I regret not pushing harder in both cases. But the thing with mistakes and bad decisions is that they come together to shape your current experiences. I might not be where I am today had I not made those mistakes. The best decision I ever made was leaving the NGO space and returning to academia in 2018; academia is my calling. I love teaching, writing, and theorising.

What does the word woman mean to you?

I think to be a woman means many different things. But at its core, it should mean inclusion and individual and collective acceptance and expression of our differences. 

Which woman inspires you, and why?

There are so many, and they all inspire me in different ways. My mothers, Prof Pearl Sithole, Prof Puleng LenkaBula, Beyonce, Patricia Hill Collins, Sisonke Msimang, Makoma Lekalakala, Nonhle Mbuthuma, and Tarana Burke. My friends, my little niece, and all the black women, living and gone – who gave up their lives so that, one day, a girl like me can enjoy certain liberties. 

What advice would you give to the 15-year-old you?

Make mistakes, it’s okay, it won’t be the end of the world. You will learn from them, but just focus on being a kid. Stop hiding in the library behind books; you learn more from life by exploring and living it, not only reading about it. Being an introvert is OK, but don’t let it make you fear people. Being an uncool becomes the new cool later, so you’ll be fine, you’ll be great!

What makes you a woman of quality, impact, and care?

My impact has been in my written work, both within academia and the mainstream media. I research, write, and theorise on a variety of topics, mainly decoloniality, indigenous knowledge, and feminism. I see my place as an emerging scholar and leader in this space not just at the UFS, but also nationally, and eventually internationally.

 

I cannot live without … a fully stocked kitchen; love cooking and baking … hate cleaning up afterwards.
My secret weapon is … kindness; I’ve had so many uncertain or tense situations go well, just because I treated people with kindness before even knowing they would be the ones I need/get help from.
I always have … my cellphone; it makes going through life so much easier, especially as a woman. It is more than just a phone, it is my panic button when I am feeling unsafe, my navigator when I am lost and scared, my bank – and most importantly – my way to connect with loved ones.
I will never … knowingly allow certain privileges I enjoy, being used against others who are more socially disenfranchised than I am.
I hope … to see my family and pet bunny Dash soon, I miss them very much.


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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