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16 August 2021 | Story Nonsindiso Qwabe | Photo Sonia Small (Kaleidoscope Studios)
New member of the Pontifical Academy of Social Sciences - Prof Pearl Sithole

Social scientist and Vice-Principal: Academic and Research on the Qwaqwa Campus, Prof Pearl Sithole, was appointed by Pope Francis as a member of the Pontifical Academy of Social Sciences for her stellar work in social sciences. 
Academicians are appointed by the Pope on the basis of their competencies in the social sciences and their moral integrity.

Prof Sithole said she was looking forward to sharing meaning and impact with the world through a space dedicated to the social sciences. “It’s a great honour. I’m feeling really humbled. The social sciences and humanities are a hugely necessary space to make meaning of the world, but for some reason, in the pecking order, they were relegated to a space that is thought of last. This appointment is to a dedicated space – to say, let’s look at issues through that lens.”
The Pontifical Academy of Social Sciences was established by Pope John Paul II in 1994 with the aim of promoting the study and progress of the social sciences, primarily economics, sociology, law, and political science. To achieve its aims, the academy organises conferences and workshops on specific themes, promotes scientific surveys and research, and publishes publications. 

Prof Sithole said the academy provides a wonderful way of reminding academicians of the importance of relating science to the real world. 

“What I like about it is that it demystifies science. It says, be excellent in your field but be able to converse for impact, be able to come to a forum that worries about specific issues, it still encourages publications and pure science/scientific endeavours, advancements in their field, but sometimes people come together to look at an issue from various angles. For me, it’s such a wonderful way of saying we must remember that we are doing science in order to relate to the world, not just to understand for the sake of understanding,” she said.

Make a genuine effort to make a difference in whatever you do, and your work will speak for itself.- Prof Pearl Sithole. 

The appointment also coincides with Women’s Month, and Prof Sithole said she takes great pride in her womanhood. 

“I am a mother and a daughter. I strive to pinpoint problems and offer solutions. I am a social scientist. I’ve made it a mission to study how systems affect people by infusing humanity within the systems. Women have been made to be apologetic about the qualities that define us as women, which we bring especially into leadership. I don’t apologise for my emotions. I don’t apologise for my multitasking abilities; however, I do feel that women are often abused for having these.”

What would you say makes you a UFS woman of quality, impact, and care?

I am the sort of person who strongly believes that your work should speak for itself. I don’t work for accolades. My approach to life is to work genuinely to make a difference, and your work will speak for itself. If you wake up every day to genuinely make a difference, it is enough. You get a lot of satisfaction in life, and you sleep better because you know you have given it your best, and you know that sometimes you can actually see it making a difference.

What advice would you give to the 15-year-old you?

I would say, be true to yourself. At a younger age, you want to chase all sorts of aspirations that look glamorous, which is not a bad thing, because you have to have appetite; but in your appetite for excellence and as someone who lives for a purpose, be true to yourself. Be able to design a life that aspires, but at the same time be adaptable to what you discover your strengths to be.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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