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27 August 2021 | Story Dr Cindé Greyling | Photo Sonia Small
Lacea Loader, an award-winning communications professional.

Lacea Loader is an award-winning communications professional who heads the UFS Department of Communication and Marketing as Director. She works with a multi-talented team that takes care of all aspects of corporate communication and marketing at the UFS. 

What is the best thing about your job?
Having a portfolio that is ever-changing and that provides me with a broad perspective of the university’s business, which is enriching and insightful. Most of all, I enjoy the people I work with in every area of my job. In general, I stand amazed at the commitment and dedication of our staff, especially during the national lockdown. It has been encouraging to experience how my team has grown and developed their skills and transitioned to the virtual workspace during this time.  

What is the best and worst decisions you have ever made?
I learn from every decision, whether it has a good or challenging impact on my life. Marrying my best friend from school and raising two beautiful, strong, and independent children are the best decisions I could have made.

What was/is the biggest challenge of your career?
The balancing act. Balancing work life and personal life; this remains a challenge throughout my career. I am trying, but I still don’t get it right!

What does the word woman mean to you?
Being able to be powerful and assertive, yet kind, gentle, compassionate, vulnerable, and understanding at the same time. 

Which woman inspires you, and why?
I work with a team of exceptional women leaders who inspire me every day. Many women at our university have reached incredible heights and put the institution on the national and international stage with their achievements. I salute all my women colleagues in whatever role they play. Also, my involvement with professional organisations and international awards programmes has given me the opportunity to work with so many women across the world in the field of communication and marketing who are making a difference in our profession. 

What advice would you give to the 15-year-old you?
Grab the opportunities that may come your way, and always think of ways to enrich yourself personally and as a professional. Remember that your character is like a tree and your reputation is like its shadow. The shadow is what others think of you; the tree is the real you.

What is the one self-care thing that you do? 
I make time to drink tea, and lots of it! Walking with my husband, spending time with my family and friends, camping and enjoying nature are some of my favourite things.

What makes you a woman of quality, impact, and care?
My intuition and sixth sense, positive mindset, and deep belief that nothing will get me down. If you ask my children, they will say it is my work ethic – as it inspires them in their studies, my kind heart, and my resilience. 
 
I cannot live without … my music playlist and a good night’s sleep.
My secret weapon is … knowing when to pause and to take time out.
I always have … a plan B.
I will never … jump from anything higher than five times my length.
I hope … to visit Easter Island, Alaska, and Norway.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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