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23 August 2021 | Story Nonsindiso Qwabe | Photo Supplied
Picture: Passionate and strong- Zanele Mbhele

Zanele Mbhele is a third-year BSc student majoring in Chemistry and Botany on the Qwaqwa Campus. At age 22, this young woman from Cornelia, a small town in the Northern Free State, already wears many hats – as a residence assistant, peer mentor for first-year students, and most recently, as a youth lifestyle blogger.

Mbhele launched her website in June. There she writes on topics such as finance, relationships, mental well-being, and fashion, to mention a few. Since its inception, she has attracted traffic from around the country, as well as international parts of the world such as North and South America, China, and different parts of Europe. 

Taking part in poetry has ignited her love for writing and storytelling, and Mbhele says she wants to grow into the many hats she wears and make a name for herself in science, as well as in writing for local and international audiences.

What does being a woman mean to you?
It’s being strong. Seeing opportunities where they are scarce. Being independent. Getting out of your comfort zone.

Which woman inspires you, and why?
It has to be news anchor and TV show host, Tumelo Mothotoane. She is from Limpopo and followed her passion for media in a place where media was not popular. She is hardworking and she believes in herself. She started small and today she is an international news anchor. Another woman who inspires me, is my mother. She was unemployed but because of her love for selling clothes, she was able to provide for us. I didn’t grow up feeling like I’m fatherless, and we were able to have a childhood like other children because of her hard work.

What advice would you give to the 15-year-old you?
I would say, invite God into all your plans. Know that no dream is too big for you. Don’t be scared of failure, because through failure we find ourselves and see our capabilities. Don’t be afraid to start small.

Any advice to anyone who also wants to grow on social media?
Social media has made many things possible. If you’re good at dancing, you can create a TikTok or YouTube account. You don’t even need fancy gadgets anymore. Many places now offer free Wi-Fi, so you can go anywhere and do your thing. Most things are possible today; you don’t have to wait until you have an iPhone. Just start with what you have. I haven’t mastered social media platforms yet and I don’t have any background in website creation, but I am learning and improving. 

What makes you a woman of quality, impact, and care?
I believe I am a woman of quality because I’m goal-driven; a woman of impact because I move beyond fear, step out of my comfort zone, and embrace change; and a woman of care because I care about the well-being of a person. This is evident from my blog. The things I talk about need little to no budget at all, because I understand what it means to be less fortunate, looking for solutions to your problems. 

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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