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14 December 2021 Photo Supplied
For Dr Katleho Tsilo, one of the latest graduates from the University of the Free State (UFS) Faculty of Health Sciences says graduating from medical school is a dream come true for her and her family.

For Dr Katleho Tsilo, one of the newest graduates from the University of the Free State (UFS) Faculty of Health Sciences, graduating from medical school does not only represent the answered prayers, persistence and sheer grace, it is also a dream come true for her and her family.

Dr Tsilo graduated on Monday 13 December 2021 during the UFS’ year-end graduating ceremonies. 

“It still feels unreal that I was able to overcome the greatest challenge that I was presented with. In my entire medical school career, I have faced many great challenges, from not having any kind of funding at all, to initially not being accepted into medicine to really having to fight for my position each and every semester while also fighting with and for my fellow students in the various leadership positions aforementioned. 

“There were moments of weakness where I wished to just quit it all, but with support from the faculty and my family, I managed to hold on. My dream was and still is bigger that any challenge that I have ever encountered,” says Dr Tsilo. 

Had various leadership positions

During her student years, this Botshabelo native engaged in various leadership positions. She also had to overcome numerous obstacles including the imposter syndrome. According to her, coming from a poor background, with very little resources, she sometimes felt insecure about what she could offer and what she is capable of. Being a health worker during the COVID-19 pandemic was also very challenging because of the uncertainty of everything and how dangerous the work environment in the hospital was proving to be.

“I was privileged enough to be elected as part of the MSA (Medical Students Association) in the Academics portfolio, this is where I then came up with the idea of collecting textbook donations and gifting the less privileged students. I was also elected to be part of the Residence Committee of the new Health Sciences Residence, in the Finance Portfolio.”

Can’t imagine doing anything else

Though she did not always want to study medicine, she ultimately decided on this field as she could not imagine doing anything else. She believes it is a calling, as she always wanted to live a life full of purpose and helping other people. Helping put a smile on someone’s face when they are going through illness is enough to change one’s life, explains Dr Tsilo about her decision to study medicine. She will be doing her internship at the Leratong Hospital in Krugersdorp, Gauteng.

Dr Tsilo, who is hoping to go into Health Science Education or Public Health, says her motivation comes from her family background. “Having been surrounded by poverty for the greater part of my life pushed me to become the difference. I was and still am determined to not be another statistic. Another thing that really motivates me is being of some help to someone. I cannot change the whole world at one time but I can surely start with one person at a time. I believe so much in the power of giving, whether knowledge, time or resources So much that I started my own foundation: the Open Hands Foundation.”

According to Dr Tsilo, her journey to graduating was intimidating – having to adjust to being a student was already tough, however adjusting to being a medical student proved to be a whole new level of challenging. It came with a lot of late nights and very early mornings, months without seeing her family and having almost no luxurious pastimes. 

But she persevered because she always had a goal and was determined to reach it. She had a vision to complete this degree and do it in record time and that’s exactly what she did. “Your vision should always fuel your mission,” says Dr Tsilo. 

Besides medicine, her other passions include charity work – something she has been doing right through her student years. 

Passion for charity work 

“I love charity work and if you did not find me studying, that’s what you would find me, doing. Open Hands is where I exercise this passion. I collect clothes, shoes and food items for the less privileged in our communities.
To students struggling and also facing difficulties, I have this simple message: Don’t stop. Don’t stop working hard, don’t stop hoping and dreaming and if you need help of any kind, it is always available. Know that you are not struggling alone, struggle is part of the journey – it always seems impossible but as long as you don’t stop you will eventually reach your destination.”

Prof Lynette van der Merwe, who took up her new position as Academic Head in the Division Health Sciences Education, Faculty of Health Sciences on 1 December 2021, congratulated the new cohort of UFS doctors and reminded them of the three Cs in the MBChB programme in 2021 – courage, conviction and compassion. She also proposed a new “C” for the year ahead: Character.  

“Character is seen in how you treat those who can do nothing for you. It takes time to develop, and only grows through suffering and failing; no shortcuts, no life hacks here. Character makes you seek to be worth knowing, rather than well known. Adam Grant says: ‘Meaning is about making a difference, not having an audience. Your legacy is not how many footprints you leave.  It’s how long they last.’ Wherever life takes you from here, whatever happens to you or through you, do what is right, not easy. Be a person of value, not success.”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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