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13 December 2021 Photo Supplied
Besides being the top medical student at UFS in 2021, Dr Mario Vieira is passionate about food, music and sport, and plays the piano and guitar for leisure.

Dr Mario Vieira, one of the University of the Free State’s (UFS) newest graduates in the MBChB programme, says he is fortunate and blessed to graduate from the Faculty of Health Sciences as the top achiever in the class of 2021. Dr Vieira will graduate at the year-end ceremonies. 

Says Dr Vieira: “Privileged is the first word that comes to mind. Yet, there are so many other emotions and feelings involved. One is relieved that the hard work is over for now, but in the same breath, quite sad that this chapter of one’s life has come to an end. Excitement also comes through, knowing that a new challenge lies ahead.” 

Dr Vieira says being the top achiever is undeniably an unbelievable achievement, but there were many other factors and people who made it possible. His family, especially his parents, were his greatest motivation. Their unconditional love and support have made his success possible. 

Multiple factors led to medicine 

According to Dr Vieira, who wanted to be a pilot when he was growing up, there were multiple factors that led to him eventually study medicine. He says: “My first experience with medicine was at a young age when I lost a good friend of mine to cancer. I believe the seed that was planted began to grow when my brother started studying medicine. 
“In high school I made the decision once I realised I was passionate about people and would love to make a difference in the life of others. I think it was the idea that if one could pass this degree, one would be equipped and capable to change lives on a daily basis. My friends in medicine and the support system in Bloemfontein were also incredibly valuable. When times were tough, we would carry each other through,” says Dr Vieira on graduating in one of the university’s toughest fields.

He is starting his internship on 1 January 2022 at Addington Hospital in Durban. 

Besides medicine, this Bothaville, Free State native is also passionate about food, music and sport. He loves cooking and hopes to retire one day with a small restaurant by the sea – cooking food and putting smiles on people’s faces. He also loves playing piano and the guitar.

His message to other students who might be considering studying medicine is: “Be courageous. You are capable of more than you think. Believe in yourself. Hard work, determination and time management can get you where you want to be.” 

Your courage 

Prof Lynette van der Merwe, who took up her new position as Academic Head in the Division Health Sciences Education, Faculty of Health Sciences on 1 December 2021, congratulated the new cohort of UFS doctors and reminded them of the three Cs in the MBChB programme in 2021 – courage, conviction and compassion.

 “I saw your courage, the way you squared your shoulders and looked personal, academic and financial problems in the eye, and endured. You were brave and strong when it mattered most. and stayed true to yourself despite overwhelming odds. You made good choices although they were hard, you found a way to put one foot in front of the other when you were too tired to even think.”

“In the words of the poet Amanda Gorman, “There is always light, if only we’re brave enough to see it. If only we’re brave enough to be it. May you always carry your light into a dark world.” 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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