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Mission: Possible

20 December 2021 | Story Igno van Niekerk | Photo Igno van Niekerk

Dr Samantha Potgieter, Senior Lecturer in the Department of Internal Medicine and Dr Nicholas Pearce, Senior Lecturer in the Department of Surgery comment on their team members’ commitment and determination during the pandemic.

On the forefront of the battle against the COVID-19 pandemic, two UFS doctors are leading a team of inspired healthcare workers in a superhuman effort to make a positive difference.

With the pandemic in its second year and the recurring challenges of new waves and strains consistently in the news, one would expect the doctors to be tired. However, quite the opposite is true. Upon entering the office where Dr Samantha Potgieter, Senior Lecturer in the Department of Internal Medicine and Dr Nicholas Pearce, Senior Lecturer in the Department of Surgery are in a meeting with colleagues, the debate is vibrant; an energetic sense of mission.

Miraculously succeeded

My brief is to collect stories and experiences they’ve had over the past 18 months at the Tumelo ward for general and high-care patients, where the team has miraculously succeeded in not running out of oxygen or ventilators, despite handling high volumes of patients from the Free State and Northern Cape. “We saw those pictures of piled-up bodies in Italy. We were committed to avoiding that at all costs. And we did.”

Success stories? First mentioned are their team members’ commitment and determination. The team had to stand in when families could not support dying patients. “They did not die alone. Our team was there.”

“Really sad and frustrating are the deaths that could have been prevented. Unvaccinated patients. They arrive ill, wanting to know if they can get it. Too late...” – Dr Nicholas Pearce

Then came hope

Sad stories? The past year has had its share of sad stories. “Someone comes in during the morning, needs oxygen, in the afternoon they are in ICU, then ventilator – and then they die. We’ve never faced anything like this before.”

Then came hope. Vaccines. Dr Pearce is in charge of the vaccination site at Universitas Hospital. “Really sad and frustrating are the deaths that could have been prevented. Unvaccinated patients. They arrive ill, wanting to know if they can get it. Too late ...” He opens his cell phone – shares the stats. “We can handle 2 000 vaccinations a day. At the moment about 250 comes in.” He shakes his head.

“We can beat this virus, but we need to stand together ...”

News Archive

Collaboration between UFS and Mayo Clinic to revolutionise cancer treatment

2014-06-27

Attending the lecture were, from the left: Dr Chantel Swart, Prof Lodewyk Kock, Prof Debabrata Mukhopadhyay, Prof James du Preez; back: Prof Pieter van Wyk. Dr Swart, Profs Kock and Du Preez are from the Department of Microbial, Biochemical and Food Biotechnology. Prof Mukhopadhyay is from the Mayo Clinic (US) and Prof Van Wyk is from the Centre for Microscopy at the UFS.
Photo: Supplied

The UFS made a discovery that may have enormous implications for the treatment of diseases in humans.

Since the discovery, the UFS joined forces with the Mayo Clinic in Rochester, US, in the fight against cancer.

In this collective effort, UFS researchers would be able to assist the Mayo team to:
• see how treatment in cancer patients is progressing,
• target treatments more effectively,
• reduce dosages in order to make treatment gentler on the patient,
• track the effectiveness of the chemotherapy drugs used, and
• gain an accurate view of how the cancer is being eliminated.

Prof Lodewyk Kock, Outstanding Professor at the Department of Microbial, Biochemical and Food Biotechnology, and his team incidentally created a technique to use argon gas particles for the first time on biological material to slice open cells to look inside.

The team that supported Prof Kock includes Dr Chantel Swart, Khumisho Dithebe (PhD student), Prof Hendrik Swart (Department of Physics) and Prof Pieter van Wyk (Centre for Microscopy).

Prof Debabrata Mukhopadhyay from the Mayo Clinic in Rochester, US, got to hear about this breakthrough at the UFS and a collaboration between the two institutions was established.

During a visit to the Bloemfontein Campus, Prof Mukhopadhyay explained novel techniques that make use of gold nanoparticles. These particles attach to chemotherapeutic drugs to selectively target cancer cells – dramatically decreasing the side effects to normal human cells.

For these new drugs (coupled to gold nanoparticles) to be accepted into clinical practice, visual and chemical proof is needed, though. This is where the technique developed by the UFS will play a vital role.

With the technique to look inside cells, the composition, location and metabolism of these drugs can be determined. This will aid in a proof of concept for the application of the nano-drugs. Furthermore, it will enable approval for use of these drugs in clinical trials and eventually could revolutionise cancer treatment as a whole.

For video lectures on the technique used, as well as its findings, follow these links:

1. http://vimeo.com/63643628 (Comic version for school kids)

2. http://vimeo.com/61521401 (Detailed version for fellow scientists)

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