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14 December 2021 | Story Leonie Bolleurs | Photo Supplied
Ofhani Mavhungu was recently awarded the Professor Rob Gous Scholarship by the Animal Feed Manufacturers Association (AFMA) of South Africa.

From a very early age, Ofhani Mavhungu knew he wanted to be involved in agriculture one day. Fast forward a few decades and you find Ofhani enrolled for the MScAgric Animal Science degree at the University of the Free State (UFS).

As a goal-orientated person who is open to new ventures, he reckons this degree will broaden his knowledge and understanding of the industry. “I believe Animal Science is an interdisciplinary field of study that enables students like me to pursue various career opportunities, ranging from primary animal production to secondary product processing, retail, and quality assurance. This motivates me to be part of the team that will ensure food security for the future generation,” says Ofhani.

Opening doors to a career in Animal Science

The Professor Rob Gous Scholarship for 2020/2021 that was jointly awarded to him and Victor Makofane of the University of Limpopo by the Animal Feed Manufacturers Association (AFMA) of South Africa, is for Ofhani a step closer to realising his dreams. 

“Diligence and hard work have always been the driving force throughout my studies, and I am delighted that my hard work was rewarded. This award further reflects on the Department of Animal Science’s dedication and commitment to build and mentor strong candidates who are recognised by the industry,” he says.

With increasing animal feed costs, the search for more cost-effective feed utilisation techniques – without compromising the nutritive value or feed quality – becomes critically important for intensive broiler producers. 

Ofhani’s study, which aims to evaluate the effect of increasing levels of a nutritional fat emulsifier with a high HLB on the (i) diet digestibility and (ii) production performance of broilers, will provide some insight into the possible energy-saving effect of dietary emulsifiers with a high HBL in broiler diets with moderate lipid inclusion levels. 

“A digestibility study will give more information on the emulsifier effect at metabolic level, and a production study will provide information on growth characteristics and carcass composition.”

An opportunity to compete with other candidates in the industry

“Few studies have been conducted on lipid emulsifiers under South African conditions, which necessitates the need for further research in this field,” he says. 

Ofhani, whose motto in life is to stay humble and accept positive criticism – as it is meant to enlighten you – wants to pursue a career in the animal feed industry. “My qualification will give me an opportunity to compete with other candidates of our generation in the industry, as well as on a research/academic level. By completing my MScAgric, I will broaden my own skill set so that I can continue with industry-related research in the future and provide mentorship to prospective animal scientists,” he adds. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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