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01 December 2021 | Story André Damons | Photo Charl Devenish
Prof Felicity Burt, expert in arbovirology in the Division of Virology at the University of the Free State (UFS) and the National Health Laboratory Service (NHLS).

Even though not much is yet known about the new COVID-19 variant, Omicron, the presence of a high number of mutations – more than 30 – in the spike protein of the variant raises concern. 

This is according to Prof Felicity Burt, expert in arbovirology in the Division of Virology at the University of the Free State (UFS) and the National Health Laboratory Service (NHLS). According to her, although Omicron is highly transmissible, further epidemiological data is required to determine if it is more transmissible than the Delta variant.

On Friday 26 November, the World Health Organisation (WHO) declared the new variant, B.1.1.529, a variant of concern (VOC) and assigned it the name Omicron. This assignation was based on advice from the Technical Advisory Group on SARS-CoV-2 Virus Evolution (TAG-VE), an independent group of experts responsible for monitoring and evaluating emerging variants. The following are considered when categorising a newly identified variant – are there mutations (changes in the viral genes) that are known, or that have the potential, to affect the characteristics of the virus, such as transmissibility, disease severity, immune escape, diagnostic or therapeutic escape; is there significant community transmission or increasing prevalence in multiple countries over time; are the public health and social measures effective against the variant.

With each new variant, the public health concerns are dependent on the transmissibility of the variant, the ability of the virus to escape immunity from natural infection or from vaccination, and the severity of illness caused by the variant or any change in clinical presentation. In addition, the ability of current diagnostic assays to adequately detect the variant and effectiveness of public health and social measures, must be considered.

We know, we don’t know 

Answers are derived from existing epidemiological data, laboratory research, and theoretical considerations. Although we can make some predictions based on the mutations identified and the location of these mutations, the epidemiological data and laboratory research are essential to answer with certainty, and this can take some time. The presence of a high number of mutations – more than 30 – in the spike protein of Omicron, raises concern. What do we know and what don’t we know?

“What we don’t know is whether these mutations have changed the severity of disease caused by the virus. We do know that the diagnostic PCR tests currently used in South Africa are not compromised by the presence of these mutations, and in fact, one of the molecular assays commonly used to target three regions of the virus, can be used as a rapid biomarker to detect the variant. Although sequencing of the genome is used as confirmation, this assay provides a useful rapid biomarker that can be used to detect the presence of the variant; subsequently, PCR results have shown that the variant is likely already present in most provinces in the country,” says Prof Burt, who currently holds an NRF-DST South African Research Chair in vector-borne and zoonotic pathogens research. 

There is also preliminary epidemiological evidence that reinfections are occurring. According to her, the occurrence of reinfections suggests some degree of immune escape; however, we do not know the extent of immune escape or the contribution of waning immunity towards reinfections. “Laboratory tests, in which the live virus is tested against samples from both recovered and vaccinated people, are required to confirm whether existing antibodies can neutralise the variant. The tests for neutralising antibodies require specialised facilities and is dependent on culturing the virus. 
“These tests are already underway in the country and should provide more information in the coming weeks. 

Neutralising antibody tests, although time consuming, are relatively easy to perform compared to tests to determine the role played by other arms of the immune response.”

Vaccines still best option to fight COVID-19

Prof Burt, who has worked on viral haemorrhagic fevers and arboviruses at the National Institute for Communicable Diseases (NICD), says it is known that vaccines are highly effective in reducing the severity of disease and fatalities in individuals infected with other variants, such as Beta and Delta, despite mutations in critical regions of the spike gene in the variants. 

The epidemiological data acquired from cases and the results of laboratory tests for neutralising capability will contribute towards understanding the effectiveness of the vaccine against Omicron. The questions regarding severity of the disease and level of protection from previous infection and vaccines are priority areas to understand the impact of this variant. The early identification of the variant and the initiation of vital research and data analysis highlight the importance of genomic surveillance.

Cases of Omicron have already been confirmed in Israel, the United Kingdom, Europe, Australia, and Africa. Travel restrictions have previously been shown to be ineffective in stopping the geographical spread of new variants, merely delaying the inevitable, and at significant cost to economies. “We know with certainty that vaccination has reduced the severity of illness and death with previous variants; even in the face of reduced neutralising ability, there was sufficient protection to save lives,” says Prof Burt.  

She concluded, “Globally, the impact of vaccination is evident in countries experiencing fourth waves, with a reduced number of deaths compared to previous waves. Many decisions in life are based on a risk assessment and consideration of the pros and cons. Vaccines save lives. Vaccines definitely boost waning immune responses from natural infection.” 

“This is certainly not the time to reject the vaccine based on perceived risks from inaccurate social media spreading harmful disinformation compared to the known risks associated with contracting COVID-19 and the known protection against severe disease afforded by the vaccines.”

News Archive

Grant encourages and enables more learners to enter into science-related studies and careers
2009-06-26

 
At the launch are, from the left, front: Consolation Mochusi, Graad 12 learner from Heatherdale Secondary School, Alexander Bergman, Grade 10 learner from Grey College Secondary School, Danél Prinsloo, Grade 11 learner from Eunice High School; middle: Ms Lea Koenig, Coordinator: ICT Laboratory of the Qwaqwa Campus, Prof. Daniela Coetzee-Manning, Director: CED; back: Ms Elna Fourie, Development Planner from SANRAL, Prof. Teuns Verschoor, Acting Rector of the UFS, Mr Cobus van Breda, Project Coordinator: CED and Mr Nazir Alli, Chief Executive Officer of SANRAL.
Photo: Stephen Collett


 

The University of the Free State’s (UFS) Centre for Education Development (CED) has this week launched a project on the Main Campus in Bloemfontein.
to enable and encourage more learners to enter into science-related studies and careers.

The grant of R4,5 million over a period of three years was made by the South African National Roads Agency Ltd (SANRAL). This week’s function was attended by the representatives of the sponsors and the UFS, as well as learners, parents, principals and Physical Sciences teachers of participating schools.

The grant will be utilised to foster a positive attitude towards Mathematics and Science amongst learners in the early school years as well as raising the knowledge and skills levels of learners in the Further Education and Training (FET) Phase. “This will be done through our Family Math and Family Science Programme for younger learners and through e-Education in Science and Mathematics for learners in the FET Phase,” said Mr Cobus van Breda, Project Coordinator at the CED.

About 330 selected Grade 10, 11 and 12 learners from 16 schools in the Free State are attending Physical Sciences and Mathematics sessions during weekdays at the ICT Laboratories on the Main and Qwaqwa Campuses of the UFS. In order to make provision for the needs of generation Y-learners (techno-clever generation), the project envisages to enhance their understanding of Science and Mathematics principles by utilising the advantages of ICTs (Information and Communication Technologies) during the sessions.

On average, learners attend four sessions per term, with one of the sessions a special event like visiting Boyden Observatory, departments at the UFS, etc. Learners will be exposed to about 36 sessions over the three years. Special attention to vocational guidance, in collaboration with the Unit for Prospective Students at the UFS, forms part of the support system of the programme to participating learners.

“Learning is a life-long experience and we must encourage our learners to grab this opportunity to learn more about important fields such as Mathematics and Science. It is a privilege for SANRAL to have this partnership with the CED and the university as it is an indication of our efforts to educate our youth,” said Mr Nazir Alli, Chief Executive Officer of SANRAL.

Mr Alli encouraged learners to grab the opportunity to learn and to make the field of science their career. “Science can be the foundation on which to build your career and this programme can assist you to reach your goal,” he said.

According to Prof. Teuns Verschoor, Acting Rector of the UFS, the SANRAL grant is a wise investment because it is an educational investment. “We cannot cut back on the investments we make in education and SANRAL’s investment in this programme is of benefit to schools and learners in the central region. Through this programme, its bursaries, various career opportunities and ongoing support of schools and universities SANRAL is making a huge contribution to promoting science-related studies and careers in our country,” he said.

Media Release
Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
26 June 2009

 

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