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01 December 2021 | Story André Damons | Photo Charl Devenish
Prof Felicity Burt, expert in arbovirology in the Division of Virology at the University of the Free State (UFS) and the National Health Laboratory Service (NHLS).

Even though not much is yet known about the new COVID-19 variant, Omicron, the presence of a high number of mutations – more than 30 – in the spike protein of the variant raises concern. 

This is according to Prof Felicity Burt, expert in arbovirology in the Division of Virology at the University of the Free State (UFS) and the National Health Laboratory Service (NHLS). According to her, although Omicron is highly transmissible, further epidemiological data is required to determine if it is more transmissible than the Delta variant.

On Friday 26 November, the World Health Organisation (WHO) declared the new variant, B.1.1.529, a variant of concern (VOC) and assigned it the name Omicron. This assignation was based on advice from the Technical Advisory Group on SARS-CoV-2 Virus Evolution (TAG-VE), an independent group of experts responsible for monitoring and evaluating emerging variants. The following are considered when categorising a newly identified variant – are there mutations (changes in the viral genes) that are known, or that have the potential, to affect the characteristics of the virus, such as transmissibility, disease severity, immune escape, diagnostic or therapeutic escape; is there significant community transmission or increasing prevalence in multiple countries over time; are the public health and social measures effective against the variant.

With each new variant, the public health concerns are dependent on the transmissibility of the variant, the ability of the virus to escape immunity from natural infection or from vaccination, and the severity of illness caused by the variant or any change in clinical presentation. In addition, the ability of current diagnostic assays to adequately detect the variant and effectiveness of public health and social measures, must be considered.

We know, we don’t know 

Answers are derived from existing epidemiological data, laboratory research, and theoretical considerations. Although we can make some predictions based on the mutations identified and the location of these mutations, the epidemiological data and laboratory research are essential to answer with certainty, and this can take some time. The presence of a high number of mutations – more than 30 – in the spike protein of Omicron, raises concern. What do we know and what don’t we know?

“What we don’t know is whether these mutations have changed the severity of disease caused by the virus. We do know that the diagnostic PCR tests currently used in South Africa are not compromised by the presence of these mutations, and in fact, one of the molecular assays commonly used to target three regions of the virus, can be used as a rapid biomarker to detect the variant. Although sequencing of the genome is used as confirmation, this assay provides a useful rapid biomarker that can be used to detect the presence of the variant; subsequently, PCR results have shown that the variant is likely already present in most provinces in the country,” says Prof Burt, who currently holds an NRF-DST South African Research Chair in vector-borne and zoonotic pathogens research. 

There is also preliminary epidemiological evidence that reinfections are occurring. According to her, the occurrence of reinfections suggests some degree of immune escape; however, we do not know the extent of immune escape or the contribution of waning immunity towards reinfections. “Laboratory tests, in which the live virus is tested against samples from both recovered and vaccinated people, are required to confirm whether existing antibodies can neutralise the variant. The tests for neutralising antibodies require specialised facilities and is dependent on culturing the virus. 
“These tests are already underway in the country and should provide more information in the coming weeks. 

Neutralising antibody tests, although time consuming, are relatively easy to perform compared to tests to determine the role played by other arms of the immune response.”

Vaccines still best option to fight COVID-19

Prof Burt, who has worked on viral haemorrhagic fevers and arboviruses at the National Institute for Communicable Diseases (NICD), says it is known that vaccines are highly effective in reducing the severity of disease and fatalities in individuals infected with other variants, such as Beta and Delta, despite mutations in critical regions of the spike gene in the variants. 

The epidemiological data acquired from cases and the results of laboratory tests for neutralising capability will contribute towards understanding the effectiveness of the vaccine against Omicron. The questions regarding severity of the disease and level of protection from previous infection and vaccines are priority areas to understand the impact of this variant. The early identification of the variant and the initiation of vital research and data analysis highlight the importance of genomic surveillance.

Cases of Omicron have already been confirmed in Israel, the United Kingdom, Europe, Australia, and Africa. Travel restrictions have previously been shown to be ineffective in stopping the geographical spread of new variants, merely delaying the inevitable, and at significant cost to economies. “We know with certainty that vaccination has reduced the severity of illness and death with previous variants; even in the face of reduced neutralising ability, there was sufficient protection to save lives,” says Prof Burt.  

She concluded, “Globally, the impact of vaccination is evident in countries experiencing fourth waves, with a reduced number of deaths compared to previous waves. Many decisions in life are based on a risk assessment and consideration of the pros and cons. Vaccines save lives. Vaccines definitely boost waning immune responses from natural infection.” 

“This is certainly not the time to reject the vaccine based on perceived risks from inaccurate social media spreading harmful disinformation compared to the known risks associated with contracting COVID-19 and the known protection against severe disease afforded by the vaccines.”

News Archive

UFS launches history book
2007-02-02

 

Attending the launch of the UFS history book were, from the left: Prof Stef Coetzee, Prof Francois Retief, Prof Wynand Mouton, Mr Pieter Cox (Chairperson on Sasol) and Prof Frederick Fourie (Rector and Vice-Chancellor of the UFS). Profs Coetzee, Retief and Mouton are former rectors of the UFS.
UFS launches history book
 
The University of the Free State (UFS) today launched its history book titled, From Grey to Gold, on the Main Campus in Bloemfontein.
 
“The history of the UFS is one of faith, hope, struggle and determination. The book tells a fascinating story that stretches over a 100 years. It is divided into five main phases, which tells about the growth of the UFS from a poor Free State community to a mature university. Interesting stories about student days, sport, rag and hostel activities are included in each phase,” Prof Frederick Fourie, Rector and Vice-Chancellor said during the launch of the book.
 
“One cannot know where you are going if you don’t know where you are coming from. You have a clearer idea of the issues facing an institution if you know the history. A book like this one is also an important source of reference for staff on the campus,” said Prof Fourie.
 
The first research for the book was done from 1999-2003 by Prof Leo Barnard from the Department of History and a team of researchers. They also compiled the first manuscript. 
 
During the last three years, Prof Fourie was closely involved with the writing of the final phase and finishing off the history book project. “It was an honour to be so closely involved with the story of the UFS because now I have a better understanding of the institution, its people, its culture and its way of thinking. For any rector of a university, such an understanding of its institution is a requirement,” Prof Fourie said.
 
The book is partly sponsored by Sasol. During the launch of the book, Mr Pieter Cox, Chairperson of Sasol said the company and the UFS have been partners for 57 years. “Both Sasol and the UFS are striving for excellence – Sasol for excellence in technology and the UFS for excellence in education,” said Mr Cox. 
 
“It was an easy decision when the UFS approached Sasol for financial support of the history book. Its a formidable piece of work, something Prof Fourie and the UFS can be proud of,” said Mr Cox.
 
The book consists of more than 500 pages with hundreds of photos and a wide range of supplements of office-bearers, awards and achievements (including national and sporting colours). A timeline framework, putting the history of the UFS in context with the history of the Free State, South Africa and of the world, is also included.
 
Besides the supplements, the history book also tells the story of amongst others the establishment of the UFS; the role of its founding fathers; black pioneers of transformation; the establishment and development of academic departments and faculties; student numbers; pioneers and trends in research; academic entrepreneurs; campus issues and campus politics; interesting facts and stories about student life (rag, intervarsity and cheerleaders, sport and the Springboks, hostel traditions); the admission of black students and anguish about race; language and culture; the development of the Main Campus; the Tickey and the Banana and much more.
 
Emphasis is placed on a very high level of quality. “It is not every day that the university becomes hundred years old and the institution will be measured by the quality of the book. We cannot say the UFS is a university of excellence if the book does not reflect that,” Ms Edma Pelzer, Director: Physical Resources and Special Projects said. Ms Pelzer managed the project as part of the last mentioned part of her portfolio.
 
The search for photographs was an important aspect of the book and it was a big task to find photographs and write captions. It took almost a year to translate and prepare the English edition and almost ten months to ensure the accuracy thereof, especially to correctly translate the typical Free State and UFS terminology and naturally to complete the English manuscript’s layout and proofreading. In the mean time the cover pages were designed and in September 2006 the manuscript went into the final print process. The Afrikaans title is: Van Sink tot Sandsteen tot Graniet.  
 
The cost of the book is R380 per copy. Those who already ordered the book will soon receive their copy. Orders can be placed by contacting Mr Dawid Kriel at UFS Marketing on 051 401 3409 or on the UFS web site at www.ufs.ac.za. The book is also available at Van Schaik Book Store on the Thakaneng Bridge, UFS Main Campus and at Fascination Books in Mimosa Mall, Bloemfontein.
 
Media release
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
2 February 2007

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