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01 December 2021 | Story André Damons | Photo Charl Devenish
Prof Felicity Burt, expert in arbovirology in the Division of Virology at the University of the Free State (UFS) and the National Health Laboratory Service (NHLS).

Even though not much is yet known about the new COVID-19 variant, Omicron, the presence of a high number of mutations – more than 30 – in the spike protein of the variant raises concern. 

This is according to Prof Felicity Burt, expert in arbovirology in the Division of Virology at the University of the Free State (UFS) and the National Health Laboratory Service (NHLS). According to her, although Omicron is highly transmissible, further epidemiological data is required to determine if it is more transmissible than the Delta variant.

On Friday 26 November, the World Health Organisation (WHO) declared the new variant, B.1.1.529, a variant of concern (VOC) and assigned it the name Omicron. This assignation was based on advice from the Technical Advisory Group on SARS-CoV-2 Virus Evolution (TAG-VE), an independent group of experts responsible for monitoring and evaluating emerging variants. The following are considered when categorising a newly identified variant – are there mutations (changes in the viral genes) that are known, or that have the potential, to affect the characteristics of the virus, such as transmissibility, disease severity, immune escape, diagnostic or therapeutic escape; is there significant community transmission or increasing prevalence in multiple countries over time; are the public health and social measures effective against the variant.

With each new variant, the public health concerns are dependent on the transmissibility of the variant, the ability of the virus to escape immunity from natural infection or from vaccination, and the severity of illness caused by the variant or any change in clinical presentation. In addition, the ability of current diagnostic assays to adequately detect the variant and effectiveness of public health and social measures, must be considered.

We know, we don’t know 

Answers are derived from existing epidemiological data, laboratory research, and theoretical considerations. Although we can make some predictions based on the mutations identified and the location of these mutations, the epidemiological data and laboratory research are essential to answer with certainty, and this can take some time. The presence of a high number of mutations – more than 30 – in the spike protein of Omicron, raises concern. What do we know and what don’t we know?

“What we don’t know is whether these mutations have changed the severity of disease caused by the virus. We do know that the diagnostic PCR tests currently used in South Africa are not compromised by the presence of these mutations, and in fact, one of the molecular assays commonly used to target three regions of the virus, can be used as a rapid biomarker to detect the variant. Although sequencing of the genome is used as confirmation, this assay provides a useful rapid biomarker that can be used to detect the presence of the variant; subsequently, PCR results have shown that the variant is likely already present in most provinces in the country,” says Prof Burt, who currently holds an NRF-DST South African Research Chair in vector-borne and zoonotic pathogens research. 

There is also preliminary epidemiological evidence that reinfections are occurring. According to her, the occurrence of reinfections suggests some degree of immune escape; however, we do not know the extent of immune escape or the contribution of waning immunity towards reinfections. “Laboratory tests, in which the live virus is tested against samples from both recovered and vaccinated people, are required to confirm whether existing antibodies can neutralise the variant. The tests for neutralising antibodies require specialised facilities and is dependent on culturing the virus. 
“These tests are already underway in the country and should provide more information in the coming weeks. 

Neutralising antibody tests, although time consuming, are relatively easy to perform compared to tests to determine the role played by other arms of the immune response.”

Vaccines still best option to fight COVID-19

Prof Burt, who has worked on viral haemorrhagic fevers and arboviruses at the National Institute for Communicable Diseases (NICD), says it is known that vaccines are highly effective in reducing the severity of disease and fatalities in individuals infected with other variants, such as Beta and Delta, despite mutations in critical regions of the spike gene in the variants. 

The epidemiological data acquired from cases and the results of laboratory tests for neutralising capability will contribute towards understanding the effectiveness of the vaccine against Omicron. The questions regarding severity of the disease and level of protection from previous infection and vaccines are priority areas to understand the impact of this variant. The early identification of the variant and the initiation of vital research and data analysis highlight the importance of genomic surveillance.

Cases of Omicron have already been confirmed in Israel, the United Kingdom, Europe, Australia, and Africa. Travel restrictions have previously been shown to be ineffective in stopping the geographical spread of new variants, merely delaying the inevitable, and at significant cost to economies. “We know with certainty that vaccination has reduced the severity of illness and death with previous variants; even in the face of reduced neutralising ability, there was sufficient protection to save lives,” says Prof Burt.  

She concluded, “Globally, the impact of vaccination is evident in countries experiencing fourth waves, with a reduced number of deaths compared to previous waves. Many decisions in life are based on a risk assessment and consideration of the pros and cons. Vaccines save lives. Vaccines definitely boost waning immune responses from natural infection.” 

“This is certainly not the time to reject the vaccine based on perceived risks from inaccurate social media spreading harmful disinformation compared to the known risks associated with contracting COVID-19 and the known protection against severe disease afforded by the vaccines.”

News Archive

Alumni inspired to keep flying the Kovsie flag high at reunion weekend festivities
2015-09-01

Dr Khotso Mokhele and Adv Roelf Meyer

The University of the Free State hosted alumni from all over the country on the Bloemfontein Campus during a weekend of exciting events, talks, and tours around the campus on 28 and 29 August 2015.

The celebratory events were kick-started with a leadership symposium hosted by Dr Marcus Ingram, Director: Institutional Advancement with Adv Roelf Meyer. The symposium was attended by current student leaders and the SRC Presidents Alumni Association. In his dialogue with the audience, Adv Meyer shared his experiences and personal growth in the process of bringing about democracy in the country with student leaders as change agents. “If you really want to contribute to change, it is not only an intellectual exercise; it is also a heart and soul thing,” he said.

The anchor event was the inaugural Chancellor’s Distinguished Alumnus Award Luncheon hosted by Chancellor, Dr Khotso Mokhele. Prof Jonathan Jansen, Vice-Chancellor and Rector, welcomed guests by highlighting the latest extraordinary achievements of UFS students and academic staff.

Keynote speaker of the day, Ms Nozizwe Madlala-Routledge, Executive Director of Inyathelo and a renowned politician, spoke of the role that universities have in preparing women for leadership roles and how they, in turn, can prepare society for female leadership.  She commended the UFS’s advancement efforts supported by the Kresge Foundation, which supports young people, to keep them in universities. “I am proud to say that the UFS’s efforts in advancement have achieved its goals.”

In his remarks, Dr Mokhele said “what draws a student back to his/her Alma Mater is the quality of the experience they had on campus.  This campus contributed to the transformation of this country through alumni such as Roelf Meyer and Kobie Coetsee.”  He said this initiative should create a lived experience for students on the university campus.  The Chancellor presented the Distinguished Alumnus Award to Adv Roelf Meyer, for his outstanding contributions to the human interests of South Africa, and his current work of facilitating peace processes around the world.

In accepting the award, Adv Meyer introduced Youth Zones, a project which he has been involved with for the past five years, empowering and supporting 40,000 youths in the Free State. In accepting the award, he said “I was a first-year student in 1960, my year group represented the most emphatic group of this university. There are many who came before and after us who well deserve this award, therefore, I accept it on behalf of all alumni.”

To wrap up the weekend’s festivities, former SRC President, Richard Chemaly, hosted the Faculty of Law alumni cocktail event at the CR Swart Auditorium.
Speaking at the event, Prof Caroline Nicholson, Dean of the Faculty of Law, said “A faculty cannot exist without its alumni, we need you to carry us.  Your continued support and collaboration is truly appreciated.”

Alumni and staff enjoyed further entertainment by well-known musical groups, Freshly-Ground and The Muses.

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