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10 February 2021 | Story Leonie Bolleurs | Photo Stephen Collett
Prof Lizette de Wet
Prof Lizette de Wet is of the opinion that there is no gender distinction between what women and men could achieve in the field of Computer Science and Informatics.

“I consider obtaining my PhD while balancing my work, my marriage, and two young daughters (who did not sleep through before reaching age four!) as one of my biggest achievements,” says Prof Lizette de Wet, Associate Professor in the Department of Computer Science and Informatics at the University of the Free State (UFS).

Many firsts

Her achievements in the field include much more than the PhD referred to. On 11 February, International Day of Women and Girls in Science, the UFS celebrates her for pioneering the human-computer interaction (HCI) research environment, specifically the evaluation of usability and user experience in diverse application areas, where she has experienced and established many firsts.

Prof De Wet was one of the first students to complete a master’s degree in this discipline at UNISA (1994). She says the external examiner for her master’s was from the University of York in the UK, as expertise in South Africa was still lacking at the time.

In the Department of Computer Science and Informatics at the UFS, she established the HCI research area. This involved undertaking research projects in the discipline and developing curricula for a second-year module, an honours module, and a master’s module. 

“The second-year module was also one of two modules on campus to first use iPads in class to assist in a blended learning approach,” she says. 

 

Taking the human being into consideration is much more important than simply concentrating on the programming code that needs to be written.– Prof Lizette de Wet


A woman’s contribution

Prof De Wet believes that in the research field of HCI, the focus is on the user and his/her overall user experience (including emotions, feelings, and competence) when using computers. “Taking the human being into consideration is much more important than simply concentrating on the programming code that needs to be written.”

Whether the human being writing the code is male or female, does not matter. Prof De Wet is of the opinion that there is no gender distinction between what women and men could achieve in the field of Computer Science and Informatics. 

“Although the students are still predominantly male, in the past few years more and more female students have enrolled for our postgraduate studies and completed it successfully, some of them with exceptional marks. In South-Africa, many women are making their mark in this discipline by being heads of departments at universities or in the private sector, by chairing national and international conferences, and by publishing ground-breaking research,” she adds.

Success with virtual reality

Over the past few years, Prof De Wet has concentrated on using brain-computer interfaces (BCIs) and virtual reality in her research. By the end of 2020, she had successfully supervised 11 master’s students and four PhD students, with one of the master’s students delivering ground-breaking research using virtual reality in the training of nursing students.

She elaborates: “The prototype involved virtually examining and evaluating a patient (with a foreign object lodged in a lung) in a virtual ward while wearing an Oculus Rift headset. The evaluation results were extremely positive and will be continued as a PhD study to investigate how to attempt to relieve motion sickness in an immersive virtual clinical simulation.”

Starting out as someone who never had the opportunity to lay her eyes on a computer during her school years, Prof De Wet is of the opinion that in South Africa – being a Third World country – there are numerous opportunities to make computers accessible to rural communities, and even to the large senior population who did not grow up with technology and might fear it.

With her passion for the profession, she not only delivers pioneering work, but also trains professionals in computer sciences who will contribute to a better tomorrow. 

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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