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10 February 2021 | Story Leonie Bolleurs | Photo Stephen Collett
Prof Lizette de Wet
Prof Lizette de Wet is of the opinion that there is no gender distinction between what women and men could achieve in the field of Computer Science and Informatics.

“I consider obtaining my PhD while balancing my work, my marriage, and two young daughters (who did not sleep through before reaching age four!) as one of my biggest achievements,” says Prof Lizette de Wet, Associate Professor in the Department of Computer Science and Informatics at the University of the Free State (UFS).

Many firsts

Her achievements in the field include much more than the PhD referred to. On 11 February, International Day of Women and Girls in Science, the UFS celebrates her for pioneering the human-computer interaction (HCI) research environment, specifically the evaluation of usability and user experience in diverse application areas, where she has experienced and established many firsts.

Prof De Wet was one of the first students to complete a master’s degree in this discipline at UNISA (1994). She says the external examiner for her master’s was from the University of York in the UK, as expertise in South Africa was still lacking at the time.

In the Department of Computer Science and Informatics at the UFS, she established the HCI research area. This involved undertaking research projects in the discipline and developing curricula for a second-year module, an honours module, and a master’s module. 

“The second-year module was also one of two modules on campus to first use iPads in class to assist in a blended learning approach,” she says. 

 

Taking the human being into consideration is much more important than simply concentrating on the programming code that needs to be written.– Prof Lizette de Wet


A woman’s contribution

Prof De Wet believes that in the research field of HCI, the focus is on the user and his/her overall user experience (including emotions, feelings, and competence) when using computers. “Taking the human being into consideration is much more important than simply concentrating on the programming code that needs to be written.”

Whether the human being writing the code is male or female, does not matter. Prof De Wet is of the opinion that there is no gender distinction between what women and men could achieve in the field of Computer Science and Informatics. 

“Although the students are still predominantly male, in the past few years more and more female students have enrolled for our postgraduate studies and completed it successfully, some of them with exceptional marks. In South-Africa, many women are making their mark in this discipline by being heads of departments at universities or in the private sector, by chairing national and international conferences, and by publishing ground-breaking research,” she adds.

Success with virtual reality

Over the past few years, Prof De Wet has concentrated on using brain-computer interfaces (BCIs) and virtual reality in her research. By the end of 2020, she had successfully supervised 11 master’s students and four PhD students, with one of the master’s students delivering ground-breaking research using virtual reality in the training of nursing students.

She elaborates: “The prototype involved virtually examining and evaluating a patient (with a foreign object lodged in a lung) in a virtual ward while wearing an Oculus Rift headset. The evaluation results were extremely positive and will be continued as a PhD study to investigate how to attempt to relieve motion sickness in an immersive virtual clinical simulation.”

Starting out as someone who never had the opportunity to lay her eyes on a computer during her school years, Prof De Wet is of the opinion that in South Africa – being a Third World country – there are numerous opportunities to make computers accessible to rural communities, and even to the large senior population who did not grow up with technology and might fear it.

With her passion for the profession, she not only delivers pioneering work, but also trains professionals in computer sciences who will contribute to a better tomorrow. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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