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10 February 2021 | Story Leonie Bolleurs | Photo Stephen Collett
Prof Lizette de Wet
Prof Lizette de Wet is of the opinion that there is no gender distinction between what women and men could achieve in the field of Computer Science and Informatics.

“I consider obtaining my PhD while balancing my work, my marriage, and two young daughters (who did not sleep through before reaching age four!) as one of my biggest achievements,” says Prof Lizette de Wet, Associate Professor in the Department of Computer Science and Informatics at the University of the Free State (UFS).

Many firsts

Her achievements in the field include much more than the PhD referred to. On 11 February, International Day of Women and Girls in Science, the UFS celebrates her for pioneering the human-computer interaction (HCI) research environment, specifically the evaluation of usability and user experience in diverse application areas, where she has experienced and established many firsts.

Prof De Wet was one of the first students to complete a master’s degree in this discipline at UNISA (1994). She says the external examiner for her master’s was from the University of York in the UK, as expertise in South Africa was still lacking at the time.

In the Department of Computer Science and Informatics at the UFS, she established the HCI research area. This involved undertaking research projects in the discipline and developing curricula for a second-year module, an honours module, and a master’s module. 

“The second-year module was also one of two modules on campus to first use iPads in class to assist in a blended learning approach,” she says. 

 

Taking the human being into consideration is much more important than simply concentrating on the programming code that needs to be written.– Prof Lizette de Wet


A woman’s contribution

Prof De Wet believes that in the research field of HCI, the focus is on the user and his/her overall user experience (including emotions, feelings, and competence) when using computers. “Taking the human being into consideration is much more important than simply concentrating on the programming code that needs to be written.”

Whether the human being writing the code is male or female, does not matter. Prof De Wet is of the opinion that there is no gender distinction between what women and men could achieve in the field of Computer Science and Informatics. 

“Although the students are still predominantly male, in the past few years more and more female students have enrolled for our postgraduate studies and completed it successfully, some of them with exceptional marks. In South-Africa, many women are making their mark in this discipline by being heads of departments at universities or in the private sector, by chairing national and international conferences, and by publishing ground-breaking research,” she adds.

Success with virtual reality

Over the past few years, Prof De Wet has concentrated on using brain-computer interfaces (BCIs) and virtual reality in her research. By the end of 2020, she had successfully supervised 11 master’s students and four PhD students, with one of the master’s students delivering ground-breaking research using virtual reality in the training of nursing students.

She elaborates: “The prototype involved virtually examining and evaluating a patient (with a foreign object lodged in a lung) in a virtual ward while wearing an Oculus Rift headset. The evaluation results were extremely positive and will be continued as a PhD study to investigate how to attempt to relieve motion sickness in an immersive virtual clinical simulation.”

Starting out as someone who never had the opportunity to lay her eyes on a computer during her school years, Prof De Wet is of the opinion that in South Africa – being a Third World country – there are numerous opportunities to make computers accessible to rural communities, and even to the large senior population who did not grow up with technology and might fear it.

With her passion for the profession, she not only delivers pioneering work, but also trains professionals in computer sciences who will contribute to a better tomorrow. 

News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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